Neuromodulation in the Spiral Ganglion: Shaping Signals from the Organ of Corti to the CNS

Neuromodulation in the Spiral Ganglion: Shaping Signals from the Organ of Corti to the CNS J. Membrane Biol. 209, 167–175 (2006) DOI: 10.1007/s00232-005-0841-9 1 2 3 4 D. Dulon , D.J. Jagger , X. Lin , R.L. Davis Laboratoire de Biologie Cellulaire et Mole´ culaire de lAudition, Hoˆ pital Pellegrin, INSERM et EA 3665 Universite´ de Bordeaux 2, 33076 Bordeaux, France Centre for Auditory Research, UCL Ear Institute, University College London, 332 Grays Inn Road, London, WC1X 8EE, United Kingdom Departments of Otolaryngology and Cell Biology, Emory Univ. School of Medicine, WBRB, Rm. 543, 615 Michael St., Atlanta, GA 30322, USA Department of Cell Biology & Neuroscience, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA Received: 4 January 2006 Introduction Signaling via P2X Receptors: Effects on Spiral Ganglion Neuron Threshold Level and Firing Hidden deep within the temporal bone, neurons of the Properties spiral ganglion have long resisted attempts to charac- ATP has been implicated in the function of various terize their endogenous electrophysiological proper- peripheral and central neurons. The localization of ties. Single-unit recordings revealed heterogeneity in ionotropic P2X receptors to post-synaptic dendritic responses to sounds of similar frequency (Kiang et al., spines in the brain suggests it acts as a fast excitatory 1965; Liberman, 1978) suggesting that these first-order The Journal of Membrane Biology Springer Journals

Neuromodulation in the Spiral Ganglion: Shaping Signals from the Organ of Corti to the CNS

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Copyright © 2006 by Springer Science+Business Media, Inc.
Life Sciences; Human Physiology; Biochemistry, general
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