Can J Anesth/J Can Anesth (2018) 65:1041–1056 https://doi.org/10.1007/s12630-018-1163-6 REVIEW ARTICLE/BRIEF REVIEW Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized- controlled trials Effets neurologiques et cognitifs associés à l’utilisation clinique du xénon : revue systématique et méta-analyse des essais randomisés contrôlés Lawrence Siu-Chun Law, MD Elaine Ah-Gi Lo, PharmD, BCPS, BCGP · · Caspar Chi-Chung Chan, MD · Tong Joo Gan, MD, MBA, FRCA, MHS, LiAc Received: 11 August 2017 / Revised: 18 April 2018 / Accepted: 25 May 2018 / Published online: 1 June 2018 © Canadian Anesthesiologists’ Society 2018 Abstract white matter abnormalities after cardiac arrest but had no Background Xenon has been shown to have positive effect on neurocognitive outcome and mortality. Xenon had neurologic effects in various pre-clinical models. This study no added value when used to treat neonatal asphyxia. systematically reviewed the randomized-controlled trials Thirteen RCTs compared neurocognitive effects of xenon (RCTs) investigating neurologic and cognitive outcomes with other anesthetic agents in surgical patients. While associated with the clinical use of xenon. xenon may be associated with improved short-term (\ Methods We searched PubMed, CENTRAL, EMBASE, three hours) cognitive outcome, no medium-term (six hours CINAHL,
Canadian Journal of Anesthesia/Journal canadien d'anesthésie – Springer Journals
Published: Jun 1, 2018
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