Psychiatric Quarterly [psaq] PH024-297918 April 28, 2001 8:36 Style ﬁle version Nov. 19th, 1999
Psychiatric Quarterly, Vol. 72, No. 3, 2001
NEUROLEPTIC USE IN THE TREATMENT
OF POST-TRAUMATIC STRESS DISORDER
Michael J. Sernyak, M.D., Thomas R. Kosten, M.D.,
Alan Fontana, Ph.D., and Robert Rosenheck, M.D.
Background. There have been few studies of the use of neuroleptics in the treat-
ment of Post-Traumatic Stress Disorder (PTSD). This study uses data from two
large outcome studies to: (1) examine demographic and treatment character-
istics associated with neuroleptic prescription in the treatment of PTSD, and
(2) compare the outcomes of neuroleptic-treated patients with those not receiv-
ing neuroleptics. Methods. A secondary analysis of an observational outcome
study of 831 inpatients and 554 outpatients (all males) receiving treatment
at the VA for combat-related PTSD was performed. Patients were classiﬁed
as having either received neuroleptics during the following year or not. Socio-
demographic characteristics, treatment and medication history and detailed
information about PTSD symptoms were obtained at baseline and 12 months.
First, the two groups were compared with respect to the demographic and
The authors are afﬁliated with the Psychiatry Service, VA Connecticut Healthcare Sys-
tem (Sernyak, Kosten, Rosenheck), VA Northeast Program Evaluation Center (Fontana,
Rosenheck); Evaluation Division of the National Center for PTSD (Fontana, Rosenheck),
Mental Illness Research Education and Clinical Center (Sernyak, Kosten, Rosenheck);
Department of Psychiatry (Sernyak, Kosten, Fontana, Rosenheck) and Department of
Public Health (Rosenheck), Yale University School of Medicine, New Haven, CT.
Address correspondence to Michael J. Sernyak, M.D., Psychiatry Service, 116A, VA
Connecticut Healthcare System, West Haven Campus, 950 Campbell Avenue, West
Haven, CT 06516; e-mail: firstname.lastname@example.org.
2001 Human Sciences Press, Inc.