Reviews in Endocrine and Metabolic Disorders (2017) 18:373–378 https://doi.org/10.1007/s11154-018-9442-7 Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the development of specialized guidelines 1 2,3,4 Stephan Petersenn & Christian A. Koch Published online: 26 February 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 The term ‘neuroendocrine neoplasms’ (NEN) covers a wide cardiac and ovarian metastases (, bone and lung metasta- range of tumors originating from neuroendocrine cells in var- ses , and on peritoneal carcinomatosis . The impor- ious organs. Heterogeneity and rarity of NEN have hampered tance of adequate grading was acknowledged with specific early diagnosis and standardized treatment for years, with guidelines for poorly-differentiated NEN [28, 29], and subse- many physicians being unaware of the clinical relevance of quently with guidelines separately for high-grade neuroendo- NEN. Although expanding knowledge of the molecular char- crine tumors and neuroendocrine carcinomas . To allow acteristics of neuroendocrine cells resulted in new diagnostic for a more standardized approach to NEN, ENETS also pub- and therapeutic possibilities, their integration into manage- lished consensus proposals on the TNM classification of fore- ment algorithms is still ongoing. Furthermore, availability of gut  and midgut/hindgut NEN . In addition,
Reviews in Endocrine and Metabolic Disorders – Springer Journals
Published: Feb 26, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera