Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the development of specialized guidelines

Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the... Reviews in Endocrine and Metabolic Disorders (2017) 18:373–378 https://doi.org/10.1007/s11154-018-9442-7 Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the development of specialized guidelines 1 2,3,4 Stephan Petersenn & Christian A. Koch Published online: 26 February 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 The term ‘neuroendocrine neoplasms’ (NEN) covers a wide cardiac and ovarian metastases ([25], bone and lung metasta- range of tumors originating from neuroendocrine cells in var- ses [26], and on peritoneal carcinomatosis [27]. The impor- ious organs. Heterogeneity and rarity of NEN have hampered tance of adequate grading was acknowledged with specific early diagnosis and standardized treatment for years, with guidelines for poorly-differentiated NEN [28, 29], and subse- many physicians being unaware of the clinical relevance of quently with guidelines separately for high-grade neuroendo- NEN. Although expanding knowledge of the molecular char- crine tumors and neuroendocrine carcinomas [30]. To allow acteristics of neuroendocrine cells resulted in new diagnostic for a more standardized approach to NEN, ENETS also pub- and therapeutic possibilities, their integration into manage- lished consensus proposals on the TNM classification of fore- ment algorithms is still ongoing. Furthermore, availability of gut [31] and midgut/hindgut NEN [32]. In addition, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in Endocrine and Metabolic Disorders Springer Journals

Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the development of specialized guidelines

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Endocrinology; Diabetes; Internal Medicine
ISSN
1389-9155
eISSN
1573-2606
D.O.I.
10.1007/s11154-018-9442-7
Publisher site
See Article on Publisher Site

Abstract

Reviews in Endocrine and Metabolic Disorders (2017) 18:373–378 https://doi.org/10.1007/s11154-018-9442-7 Neuroendocrine neoplasms – still a challenge despite major advances in clinical care with the development of specialized guidelines 1 2,3,4 Stephan Petersenn & Christian A. Koch Published online: 26 February 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 The term ‘neuroendocrine neoplasms’ (NEN) covers a wide cardiac and ovarian metastases ([25], bone and lung metasta- range of tumors originating from neuroendocrine cells in var- ses [26], and on peritoneal carcinomatosis [27]. The impor- ious organs. Heterogeneity and rarity of NEN have hampered tance of adequate grading was acknowledged with specific early diagnosis and standardized treatment for years, with guidelines for poorly-differentiated NEN [28, 29], and subse- many physicians being unaware of the clinical relevance of quently with guidelines separately for high-grade neuroendo- NEN. Although expanding knowledge of the molecular char- crine tumors and neuroendocrine carcinomas [30]. To allow acteristics of neuroendocrine cells resulted in new diagnostic for a more standardized approach to NEN, ENETS also pub- and therapeutic possibilities, their integration into manage- lished consensus proposals on the TNM classification of fore- ment algorithms is still ongoing. Furthermore, availability of gut [31] and midgut/hindgut NEN [32]. In addition,

Journal

Reviews in Endocrine and Metabolic DisordersSpringer Journals

Published: Feb 26, 2018

References

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