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Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial

Nested case–control study of telomere length and lung cancer risk among heavy smokers in the... www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Cancer Springer Journals

Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Cancer Research UK
Subject
Biomedicine; Biomedicine, general; Cancer Research; Epidemiology; Molecular Medicine; Oncology; Drug Resistance
ISSN
0007-0920
eISSN
1532-1827
DOI
10.1038/s41416-018-0075-0
Publisher site
See Article on Publisher Site

Abstract

www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere

Journal

British Journal of Cancer – Springer Journals

Published: Apr 19, 2018

References

  • Role of telomeres and telomerase in genomic instability, senescence and cancer
    Deng, Y; Chang, S
  • Telomere length profiles in humans: all ends are not equal
    Gilson, E; Londono-Vallejo, A
  • Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells
    Bull, CF
  • Obesity, cigarette smoking, and telomere length in women
    Valdes, AM
  • A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer
    Shen, M
  • Oxidative stress shortens telomeres
    Zglinicki, T
  • Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia
    Tchirkov, A; Lansdorp, PM
  • Cumulative inflammatory load is associated with short leukocyte telomere length in the health, aging and body composition study
    O’Donovan, A
  • Telomeres and immunological diseases of aging
    Andrews, NP; Fujii, H; Goronzy, JJ; Weyand, CM
  • Telomere length assessment: biomarker of chronic oxidative stress?
    Houben, JM; Moonen, HJ; Schooten, FJ; Hageman, GJ
  • The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life
    Graakjaer, J
  • Heterogeneity in telomere length of human chromosomes
    Lansdorp, PM
  • Short telomeres on human chromosome 17p
    Martens, UM
  • Telomere dysfunction: a potential cancer predisposition factor
    Wu, X
  • Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility
    Hosgood, HD; Cawthon, R; He, X; Chanock, S; Lan, Q
  • Telomere length and the risk of lung cancer
    Jang, JS
  • Long telomeres and cancer risk among 95 568 individuals from the general population
    Rode, L; Nordestgaard, BG; Bojesen, SE
  • Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians
    Sanchez-Espiridion, B
  • Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts
    Seow, WJ
  • Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Alberg, AJ; Ford, JG; Samet, JM
  • Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
    Omenn, GS
  • Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial
    Omenn, GS
  • The beta-carotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements
    Goodman, GE
  • Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers
    Sakoda, L
  • Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR
    Aviv, A
  • Telomere length, cigarette smoking, and bladder cancer risk in men and women
    McGrath, M; Wong, JY; Michaud, D; Hunter, DJ; Vivo, I
  • Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer
    Xing, J
  • Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and thers2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China
    Lan, Q
  • The association of telomere length in peripheral blood cells with cancer risk: a systematic review and meta-analysis of prospective studies
    Zhang, X
  • Telomere length varies by DNA extraction method: implications for epidemiologic research
    Cunningham, JM
  • Telomere length varies by DNA extraction method: implications for epidemiologic research-letter
    Hofmann, JN
  • Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study
    Zhang, C
  • Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
    Haycock, PC
  • Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia
    Machiela, MJ