www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efﬁcacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere
British Journal of Cancer – Springer Journals
Published: Apr 19, 2018
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