Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial

Nested case–control study of telomere length and lung cancer risk among heavy smokers in the... www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Cancer Springer Journals

Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Cancer Research UK
Subject
Biomedicine; Biomedicine, general; Cancer Research; Epidemiology; Molecular Medicine; Oncology; Drug Resistance
ISSN
0007-0920
eISSN
1532-1827
D.O.I.
10.1038/s41416-018-0075-0
Publisher site
See Article on Publisher Site

Abstract

www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere

Journal

British Journal of Cancer – Springer Journals

Published: Apr 19, 2018

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