Neoadjuvant Therapy Improves Outcomes in Locally Advanced Signet-Ring-Cell Containing Esophagogastric Adenocarcinomas

Neoadjuvant Therapy Improves Outcomes in Locally Advanced Signet-Ring-Cell Containing... Ann Surg Oncol (2018) 25:2418–2427 https://doi.org/10.1245/s10434-018-6541-3 O R I G IN AL ARTI CL E – GA STROIN TESTINA L O N C OLO G Y Neoadjuvant Therapy Improves Outcomes in Locally Advanced Signet-Ring-Cell Containing Esophagogastric Adenocarcinomas 1 1 1 1 Ulrike Heger, MD , Leila Sisic, MD , Henrik Nienhu¨ser, MD , Susanne Blank, MD , 1 2 3 1 Ulf Hinz, MSc , Georg Martin Haag, MD , Katja Ott, MD , Alexis Ulrich, MD , 1 1 Markus W. Bu¨chler, MD , and Thomas Schmidt, MD, PhD 1 2 Department of General, Visceral and Transplant Surgery, University Hospital, Heidelberg, Germany; National Center for Tumor Diseases (NCT), University Hospital, Heidelberg, Germany; Department of Surgery, Rosenheim, Germany ABSTRACT neoadjuvant treatment {median survival 28.5 months (95% Background. Only a few studies have analyzed multi- confidence interval [CI] 14.4–39.6) vs. RES: 14.9 months modal treatment concepts in the subgroup of signet-ring- (10.6–17.5); P \ 0.001}, as well as in subgroups (AEG and cell containing upper gastrointestinal (GI) cancer. Recent gastric tumors, R0-resected patients, and patients with and retrospective, multicentric data favor primary resection without relevant comorbidities). Independent prognostic without neoadjuvant chemotherapy for gastric signet-ring- factors were neoadjuvant therapy (hazard ratio http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgical Oncology Springer Journals

Neoadjuvant Therapy Improves Outcomes in Locally Advanced Signet-Ring-Cell Containing Esophagogastric Adenocarcinomas

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Society of Surgical Oncology
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
1068-9265
eISSN
1534-4681
D.O.I.
10.1245/s10434-018-6541-3
Publisher site
See Article on Publisher Site

Abstract

Ann Surg Oncol (2018) 25:2418–2427 https://doi.org/10.1245/s10434-018-6541-3 O R I G IN AL ARTI CL E – GA STROIN TESTINA L O N C OLO G Y Neoadjuvant Therapy Improves Outcomes in Locally Advanced Signet-Ring-Cell Containing Esophagogastric Adenocarcinomas 1 1 1 1 Ulrike Heger, MD , Leila Sisic, MD , Henrik Nienhu¨ser, MD , Susanne Blank, MD , 1 2 3 1 Ulf Hinz, MSc , Georg Martin Haag, MD , Katja Ott, MD , Alexis Ulrich, MD , 1 1 Markus W. Bu¨chler, MD , and Thomas Schmidt, MD, PhD 1 2 Department of General, Visceral and Transplant Surgery, University Hospital, Heidelberg, Germany; National Center for Tumor Diseases (NCT), University Hospital, Heidelberg, Germany; Department of Surgery, Rosenheim, Germany ABSTRACT neoadjuvant treatment {median survival 28.5 months (95% Background. Only a few studies have analyzed multi- confidence interval [CI] 14.4–39.6) vs. RES: 14.9 months modal treatment concepts in the subgroup of signet-ring- (10.6–17.5); P \ 0.001}, as well as in subgroups (AEG and cell containing upper gastrointestinal (GI) cancer. Recent gastric tumors, R0-resected patients, and patients with and retrospective, multicentric data favor primary resection without relevant comorbidities). Independent prognostic without neoadjuvant chemotherapy for gastric signet-ring- factors were neoadjuvant therapy (hazard ratio

Journal

Annals of Surgical OncologySpringer Journals

Published: May 31, 2018

References

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