Nelarabine Reactions 1680, p251 - 2 Dec 2017 Sensory neuropathy: case report A 73-year-old man developed sensory neuropathy during treatment with nelarabine. The man, who had a history of relapsing acute lymphoblastic leukaemia, started receiving treatment with IV nelarabine 1500 mg/m on days 1, 3 and 5 every 21 days. Subsequently, he developed a severe sensory neuropathy of his bilateral lower extremities with profound disturbance in the large fiber/ dorsal column function because of nelarabine [duration of treatment to reaction onset not stated]. The authors considered sensory neuropathy to be serious. The treatment with nelarabine was stopped. He started receiving treatment with decitabine. At nine months follow-up, he showed improvement in his peripheral neuropathy. Author comment: "[H]e developed a severe sensory neuropathy . . . attributed to nelarabine". El Chaer F, et al. Durable remission with salvage decitabine and donor lymphocyte infusion (DLI) for relapsed early T-cell precursor ALL. Bone Marrow Transplantation 52: 1583-1584, No. 11, Nov 2017. Available from: URL: http:// - USA 803285149 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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