Nelarabine

Nelarabine Reactions 1680, p251 - 2 Dec 2017 Sensory neuropathy: case report A 73-year-old man developed sensory neuropathy during treatment with nelarabine. The man, who had a history of relapsing acute lymphoblastic leukaemia, started receiving treatment with IV nelarabine 1500 mg/m on days 1, 3 and 5 every 21 days. Subsequently, he developed a severe sensory neuropathy of his bilateral lower extremities with profound disturbance in the large fiber/ dorsal column function because of nelarabine [duration of treatment to reaction onset not stated]. The authors considered sensory neuropathy to be serious. The treatment with nelarabine was stopped. He started receiving treatment with decitabine. At nine months follow-up, he showed improvement in his peripheral neuropathy. Author comment: "[H]e developed a severe sensory neuropathy . . . attributed to nelarabine". El Chaer F, et al. Durable remission with salvage decitabine and donor lymphocyte infusion (DLI) for relapsed early T-cell precursor ALL. Bone Marrow Transplantation 52: 1583-1584, No. 11, Nov 2017. Available from: URL: http:// doi.org/10.1038/bmt.2017.191 - USA 803285149 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Nelarabine

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39182-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p251 - 2 Dec 2017 Sensory neuropathy: case report A 73-year-old man developed sensory neuropathy during treatment with nelarabine. The man, who had a history of relapsing acute lymphoblastic leukaemia, started receiving treatment with IV nelarabine 1500 mg/m on days 1, 3 and 5 every 21 days. Subsequently, he developed a severe sensory neuropathy of his bilateral lower extremities with profound disturbance in the large fiber/ dorsal column function because of nelarabine [duration of treatment to reaction onset not stated]. The authors considered sensory neuropathy to be serious. The treatment with nelarabine was stopped. He started receiving treatment with decitabine. At nine months follow-up, he showed improvement in his peripheral neuropathy. Author comment: "[H]e developed a severe sensory neuropathy . . . attributed to nelarabine". El Chaer F, et al. Durable remission with salvage decitabine and donor lymphocyte infusion (DLI) for relapsed early T-cell precursor ALL. Bone Marrow Transplantation 52: 1583-1584, No. 11, Nov 2017. Available from: URL: http:// doi.org/10.1038/bmt.2017.191 - USA 803285149 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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