Negative correlation between viral load and HBsAg levels in chronic HBV-infected patients

Negative correlation between viral load and HBsAg levels in chronic HBV-infected patients The objective of this study is to reveal the relationship between viral load (as HBV DNA) and HBsAg levels. Ninety-two chronically HBV-infected patients were included in the study. The patients were divided in two different groups: the cirrhotic group ( n = 32) and the non-cirrhotic group ( n = 60). The correlation between study groups was also examined with regard to HBeAg status. Hepatitis B viral markers (HBsAg, HBeAg, Anti-HBs, anti-HBc and anti-HBe) and HBV viral load of the patients were measured. A significant negative correlation between HBV DNA and HBsAg levels was found in the non-cirrhotic group ( p < 0.01). The anti-HBc level was higher in the non-cirrhotic group than in the cirrhotic group ( p < 0.016). The viral load was significantly higher in HBeAg (+) patients in comparison with HBeAg (−) cases ( p < 0.0001). The HBsAg level was low in HBeAg (+) patients, whereas it was higher in HBeAg (−) cases ( p < 0.001). In conclusion, a significant negative correlation between viral load and HBsAg levels was detected in the non-cirrhotic chronically HBV-infected group. Therefore, concomitantly low HBsAg and HBV DNA levels may indicate a better prognosis compared to high HBsAg and low HBV DNA levels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Negative correlation between viral load and HBsAg levels in chronic HBV-infected patients

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-009-0474-x
Publisher site
See Article on Publisher Site

Abstract

The objective of this study is to reveal the relationship between viral load (as HBV DNA) and HBsAg levels. Ninety-two chronically HBV-infected patients were included in the study. The patients were divided in two different groups: the cirrhotic group ( n = 32) and the non-cirrhotic group ( n = 60). The correlation between study groups was also examined with regard to HBeAg status. Hepatitis B viral markers (HBsAg, HBeAg, Anti-HBs, anti-HBc and anti-HBe) and HBV viral load of the patients were measured. A significant negative correlation between HBV DNA and HBsAg levels was found in the non-cirrhotic group ( p < 0.01). The anti-HBc level was higher in the non-cirrhotic group than in the cirrhotic group ( p < 0.016). The viral load was significantly higher in HBeAg (+) patients in comparison with HBeAg (−) cases ( p < 0.0001). The HBsAg level was low in HBeAg (+) patients, whereas it was higher in HBeAg (−) cases ( p < 0.001). In conclusion, a significant negative correlation between viral load and HBsAg levels was detected in the non-cirrhotic chronically HBV-infected group. Therefore, concomitantly low HBsAg and HBV DNA levels may indicate a better prognosis compared to high HBsAg and low HBV DNA levels.

Journal

Archives of VirologySpringer Journals

Published: Sep 1, 2009

References

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