Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Cooreman, M. Roosmalen, R. Morsche, C. Sünnen, E. Ven, J. Jansen, G. Tytgat, P. Wit, W. Paulij (1999)
Characterization of the reactivity pattern of murine monoclonal antibodies against wild‐type hepatitis B surface antigen to g145r and other naturally occurring “a” loop escape mutationsHepatology, 30
B. Rehermann, M. Manns (1996)
Immunologic aspects of acute and chronic hepatitis B and CCurrent Opinion in Gastroenterology, 12
P. Paterlini, F. Driss, B. Nalpas, E. Pisi, D. Franco, P. Berthelot, C. Bréchot (1993)
Persistence of Hepatitis B and Hepatitis C Viral Genomes in Primary Liver Cancers from HBsAg‐Negative Patients: A Study of a Low‐endemic AreaHepatology, 17
J. Wands, V. Zurawski (1981)
High affinity monoclonal antibodies to hepatitis B surface antigen (HBsAg) produced by somatic cell hybrids.Gastroenterology, 80 2
Y. Asahina, Nobuyuki Enomoto, Y. Ogura, M. Kurosaki, I. Sakuma, Namiki Izumi, F. Marumo, C. Sato (1996)
Sequential changes in full-length genomes of hepatitis B virus accompanying acute exacerbation of chronic hepatitis B.Journal of hepatology, 25 6
H. Stirk, J. Thornton, C. Howard (1992)
A topological model for hepatitis B surface antigen.Intervirology, 33 3
A. Parés, J. Barrera, J. Caballería, G. Ercilla, M. Bruguera, L. Caballería, R. Castillo, J. Rodés (1990)
Hepatitis C virus antibodies in chronic alcoholic patients: Association with severity of liver injuryHepatology, 12
Wei Chen, C. Oon, Ivy Toh (2000)
Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common “a” determinantAmerican Journal of Gastroenterology, 95
K. Weinberger, Tanja Bauer, Stephan Böhm, W. Jilg (2000)
High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum.The Journal of general virology, 81 Pt 5
J. Lei, Xu Yang, Hong-Yu Luo, Wen‐long Wang, Li Huang (2006)
[Serum HBsAg concentration and HBV replication level in hepatitis B patients with positive serum HBsAg and HBeAg].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 31 4
Yao Xie, Hui Zhao, W. Dai, Dao-zhen Xu (2003)
HBV DNA level and antigen concentration in evaluating liver damage of patients with chronic hepatitis B.Hepatobiliary & pancreatic diseases international : HBPD INT, 2 3
C. Mendenhall, L. Seeff, A. Diehl, S. Ghosn, S. French, P. Gartside, S. Rouster, Z. Buskell‐Bales, C. Grossman, G. Roselle, R. Weesner, P. García-Pont, S. Goldberg, T. Kiernan, C. Tamburro, R. Zetterman, A. Chedid, Thomas Chen, L. Rabin (1991)
Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: Their prevalence and clinical relevanceHepatology, 14
Jonathan Brown, W. Carman, H. Thomas (1992)
The clinical significance of molecular variation within the hepatitis B virus genomeHepatology, 15
Matsuo Deguchi, N. Yamashita, M. Kagita, S. Asari, Y. Iwatani, T. Tsuchida, K. Iinuma, I. Mushahwar (2004)
Quantitation of hepatitis B surface antigen by an automated chemiluminescent microparticle immunoassay.Journal of virological methods, 115 2
Ronald Kennedy, I. Ionescu‐Matiu, Karen Adler-Storthz, Richard Henkel, Y. Sanchez, G. Dreesman (1983)
Characterization of anti-hepatitis B surface antigen monoclonal antibodies.Intervirology, 19 3
P. Bhatnagar, E. Papas, H. Blum, D. Milich, D. Nitecki, M. Karels, G. Vyas (1982)
Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant.Proceedings of the National Academy of Sciences of the United States of America, 79 14
P. Tiollais (1987)
[Hepatitis B virus].La Revue du praticien, 37 42
R. Perrillo (2010)
Hepatitis B and D
M. Sawada, A. Takada, A. Takada, S. Takase, N. Takada (1993)
Effects of alcohol on the replication of hepatitis C virus.Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1B
W. Carman, F. Deursen, L. Mimms, D. Hardie, R. Coppola, R. Decker, R. Sanders (1997)
The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa, and SardiniaHepatology, 26
H. Hsu, Mei‐Hwei Chang, Y. Ni, Hopi Lin, Sheng-Han Wang, Ding‐Shinn Chen (1997)
Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxisHepatology, 26
S. Caldwell, X. li, Rourk Rm, A. Millar, K. Sosnowski, M. Sue, A. Barritt, R. McCallum, E. Schiff (1993)
Hepatitis C infection by polymerase chain reaction in alcoholics: false-positive ELISA results and the influence of infection on a clinical prognostic score.The American journal of gastroenterology, 88 7
Thomas Hc, Carman Wf (1994)
Envelope and precore/core variants of hepatitis B virus.Gastroenterology Clinics of North America, 23
P. Paterlini, K. Poussin, M. Kew, D. Franco, C. Bréchot (1995)
Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinomaHepatology, 21
C. Howard, L. Allison (1995)
Hepatitis B surface antigen variation and protective immunity.Intervirology, 38 1-2
Y. Poovorawan, A. Theamboonlers, V. Chongsrisawat, S. Sanpavat (1998)
Molecular analysis of the a determinant of HBsAg in children of HBeAg-positive mothers upon failure of postexposure prophylaxis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2 4
The objective of this study is to reveal the relationship between viral load (as HBV DNA) and HBsAg levels. Ninety-two chronically HBV-infected patients were included in the study. The patients were divided in two different groups: the cirrhotic group ( n = 32) and the non-cirrhotic group ( n = 60). The correlation between study groups was also examined with regard to HBeAg status. Hepatitis B viral markers (HBsAg, HBeAg, Anti-HBs, anti-HBc and anti-HBe) and HBV viral load of the patients were measured. A significant negative correlation between HBV DNA and HBsAg levels was found in the non-cirrhotic group ( p < 0.01). The anti-HBc level was higher in the non-cirrhotic group than in the cirrhotic group ( p < 0.016). The viral load was significantly higher in HBeAg (+) patients in comparison with HBeAg (−) cases ( p < 0.0001). The HBsAg level was low in HBeAg (+) patients, whereas it was higher in HBeAg (−) cases ( p < 0.001). In conclusion, a significant negative correlation between viral load and HBsAg levels was detected in the non-cirrhotic chronically HBV-infected group. Therefore, concomitantly low HBsAg and HBV DNA levels may indicate a better prognosis compared to high HBsAg and low HBV DNA levels.
Archives of Virology – Springer Journals
Published: Sep 1, 2009
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.