Pharm Res (2018) 35:94 https://doi.org/10.1007/s11095-018-2366-9 RESEARCH PAPER Nebulization of Cyclic Arginine-Glycine-(D)-Aspartic Acid-Peptide Grafted and Drug Encapsulated Liposomes for Inhibition of Acute Lung Injury 1 2 3 Hari R. Desu & Laura A. Thoma & George C. Wood Received: 20 October 2017 /Accepted: 10 February 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT tract, especially alveolar region, Among the formulations, cRGD Purpose Acute lung injury (ALI) is a fatal syndrome in criti- MPS-L caused significant reduction of edema, neutro- cally ill patients. It is characterized by lung edema and inflam- phil infiltration and inflammation biochemical marker levels. mation. Numerous pro-inflammatory mediators are released Conclusion From the results, it can be inferred that nebuliza- into alveoli. Among them, interleukin-1beta (IL-1β)causesan tion of targeted liposomes had facilitated spatial and temporal increase in solute permeability across the alveolar-capillary modulation of drug delivery resulting in alleviation of ALI. barrier leading to edema. It activates key effector cells (alveo- lar epithelial and endothelial cells) releasing inflammatory . . . KEY WORDS drug delivery formulation inflammation chemokines and cytokines. The purpose of the study was to demonstrate that nebulized liposomes inhibit ALI in vivo. liposome nebulization Methods In vivo ALI model was
Pharmaceutical Research – Springer Journals
Published: Mar 13, 2018
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