J Gastroenterol (2017) 52:1041–1050 DOI 10.1007/s00535-017-1315-4 O R I G IN AL ARTI CL E—LIV E R, PA NCREA S , A ND BIL I ARY T RA CT Natural history of chronic hepatitis B virus infection in children in Japan: a comparison of mother-to-child transmission with horizontal transmission 1 1 2 3 • • • • Tomoko Takano Hitoshi Tajiri Satoyo Hosono Ayano Inui 4 5 6 7 • • • • Jun Murakami Kosuke Ushijima Yoko Miyoshi Yuri Etani 8 9 10 • • Daiki Abukawa Mitsuyoshi Suzuki Stephen Brooks Received: 8 August 2016 / Accepted: 28 January 2017 / Published online: 9 February 2017 Japanese Society of Gastroenterology 2017 Abstract most prevalent virus genotype (83%). Children with hori- Background It is necessary to evaluate the natural history zontal transmission were more frequently infected with of children with hepatitis B virus (HBV) infection in each HBV genotype A or B and more likely to receive interferon country to consider their long-term management. therapy than those infected by MTCT. The HBeAg sero- Methods A multi-center observational study of children conversion rate at 15 years of age was 42% in the MTCT with chronic HBV infection who were diagnosed
Journal of Gastroenterology – Springer Journals
Published: Feb 9, 2017
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