National serosurvey of encephalomyocarditis virus in healthy people and pigs in China

National serosurvey of encephalomyocarditis virus in healthy people and pigs in China Encephalomyocarditis virus (EMCV) is a zoonotic pathogen that has a wide spectrum of host range. The virus has been discovered on swine farms worldwide and can cause acute fatal myocarditis in piglets and reproductive disorders in sows. Although EMCV infection has been documented in farmed pigs in China, seroprevalence in humans has not been reported. In this study, we conducted nationwide serological surveys for EMCV in humans and farmed pigs in China in 2013, by the use of a double antigen sandwich ELISA method. A total of 3305 serum samples from healthy people were obtained from seven geographical regions in China, of which 1010 samples (30.56 %) were positive for EMCV antibodies. The overall seroprevalence for EMCV in the age groups of 0–20, 21–40, 41–60 and >60 years were 13.5 %, 30.25 %, 36.83 % and 38.71 % respectively, showing a tendency of increasing with age ( P = 0.000). A total of 3470 serum samples from farmed pigs were collected and tested for antibodies to EMCV. A high seroprevalence of 77 % was recorded, and significant regional differences were observed. It was concluded that people and pigs in China were commonly infected by EMCV. In addition, in order to characterize changes of seroprevalence during natural EMCV infection in pigs, 240 serial serum samples were collected from 30 pigs (at 0, 15, 30, 60, 75, 90, 120, and 150 days of age) in a farrow-to-finish farm in China. The data showed that there were two EMCV antibody peaks: the first peak appeared at day 30, followed by a decrease in EMCV antibody titer, and the second occurred after day 75. Thus, the most susceptible period of pigs for EMCV infection was between day 30 and day 75 of age. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

National serosurvey of encephalomyocarditis virus in healthy people and pigs in China

Loading next page...
 
/lp/springer_journal/national-serosurvey-of-encephalomyocarditis-virus-in-healthy-people-aTqY0qBzJe
Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2591-z
Publisher site
See Article on Publisher Site

Abstract

Encephalomyocarditis virus (EMCV) is a zoonotic pathogen that has a wide spectrum of host range. The virus has been discovered on swine farms worldwide and can cause acute fatal myocarditis in piglets and reproductive disorders in sows. Although EMCV infection has been documented in farmed pigs in China, seroprevalence in humans has not been reported. In this study, we conducted nationwide serological surveys for EMCV in humans and farmed pigs in China in 2013, by the use of a double antigen sandwich ELISA method. A total of 3305 serum samples from healthy people were obtained from seven geographical regions in China, of which 1010 samples (30.56 %) were positive for EMCV antibodies. The overall seroprevalence for EMCV in the age groups of 0–20, 21–40, 41–60 and >60 years were 13.5 %, 30.25 %, 36.83 % and 38.71 % respectively, showing a tendency of increasing with age ( P = 0.000). A total of 3470 serum samples from farmed pigs were collected and tested for antibodies to EMCV. A high seroprevalence of 77 % was recorded, and significant regional differences were observed. It was concluded that people and pigs in China were commonly infected by EMCV. In addition, in order to characterize changes of seroprevalence during natural EMCV infection in pigs, 240 serial serum samples were collected from 30 pigs (at 0, 15, 30, 60, 75, 90, 120, and 150 days of age) in a farrow-to-finish farm in China. The data showed that there were two EMCV antibody peaks: the first peak appeared at day 30, followed by a decrease in EMCV antibody titer, and the second occurred after day 75. Thus, the most susceptible period of pigs for EMCV infection was between day 30 and day 75 of age.

Journal

Archives of VirologySpringer Journals

Published: Dec 1, 2015

References

  • Genomic analysis of two porcine encephalomyocarditis virus strains isolated in China
    Zhang, GQ; Ge, XN; Guo, X; Yang, HC
  • Encephalomyocarditis virus disease of pigs associated with a plague of rodents
    Seaman, JT; Boulton, JG; Carrigan, MJ
  • Molecular analysis of encephalomyocarditis viruses isolated from pigs and rodents in Italy
    Knowles, NJ; Dickinson, ND; Wilsden, G; Carra, E; Brocchi, E; Simone, F
  • Encephalomyocarditis in Korea: serological survey in pigs and phylogenetic analysis of two historical isolates
    An, DJ; Jeong, W; Jeoung, HY; Yoon, SH; Kim, HJ; Choi, CU; Park, BK

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off