National serosurvey of encephalomyocarditis virus in healthy people and pigs in China

National serosurvey of encephalomyocarditis virus in healthy people and pigs in China Encephalomyocarditis virus (EMCV) is a zoonotic pathogen that has a wide spectrum of host range. The virus has been discovered on swine farms worldwide and can cause acute fatal myocarditis in piglets and reproductive disorders in sows. Although EMCV infection has been documented in farmed pigs in China, seroprevalence in humans has not been reported. In this study, we conducted nationwide serological surveys for EMCV in humans and farmed pigs in China in 2013, by the use of a double antigen sandwich ELISA method. A total of 3305 serum samples from healthy people were obtained from seven geographical regions in China, of which 1010 samples (30.56 %) were positive for EMCV antibodies. The overall seroprevalence for EMCV in the age groups of 0–20, 21–40, 41–60 and >60 years were 13.5 %, 30.25 %, 36.83 % and 38.71 % respectively, showing a tendency of increasing with age ( P = 0.000). A total of 3470 serum samples from farmed pigs were collected and tested for antibodies to EMCV. A high seroprevalence of 77 % was recorded, and significant regional differences were observed. It was concluded that people and pigs in China were commonly infected by EMCV. In addition, in order to characterize changes of seroprevalence during natural EMCV infection in pigs, 240 serial serum samples were collected from 30 pigs (at 0, 15, 30, 60, 75, 90, 120, and 150 days of age) in a farrow-to-finish farm in China. The data showed that there were two EMCV antibody peaks: the first peak appeared at day 30, followed by a decrease in EMCV antibody titer, and the second occurred after day 75. Thus, the most susceptible period of pigs for EMCV infection was between day 30 and day 75 of age. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

National serosurvey of encephalomyocarditis virus in healthy people and pigs in China

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2591-z
Publisher site
See Article on Publisher Site

References

  • Genomic analysis of two porcine encephalomyocarditis virus strains isolated in China
    Zhang, GQ; Ge, XN; Guo, X; Yang, HC
  • Encephalomyocarditis virus disease of pigs associated with a plague of rodents
    Seaman, JT; Boulton, JG; Carrigan, MJ
  • Molecular analysis of encephalomyocarditis viruses isolated from pigs and rodents in Italy
    Knowles, NJ; Dickinson, ND; Wilsden, G; Carra, E; Brocchi, E; Simone, F
  • Encephalomyocarditis in Korea: serological survey in pigs and phylogenetic analysis of two historical isolates
    An, DJ; Jeong, W; Jeoung, HY; Yoon, SH; Kim, HJ; Choi, CU; Park, BK

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