J Mater Sci: Mater Med (2017) 28:113 DOI 10.1007/s10856-017-5925-4 DELIVERY SYSTEMS Original Research Nanostructured SBA-15 host applied in ketorolac tromethamine release system 1 1 1 ● ● ● Jorgelina Cussa Juliana M. Juárez Marcos B. Gómez Costa Oscar A. Anunziata Received: 23 November 2016 / Accepted: 9 June 2017 © Springer Science+Business Media, LLC 2017 Abstract The ordered mesoporous silica SBA-15 has been Graphical Abstract Release proﬁle of KETO from SBA- 15/KETO and control releases. applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo- gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten ) and Keto solution (Keto power)
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Jun 17, 2017
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