Nano-TiCl2/cellulose: an eco-friendly bio-based catalyst for one-pot synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives

Nano-TiCl2/cellulose: an eco-friendly bio-based catalyst for one-pot synthesis of... & Bi Bi Fatameh Mirjalili Department of Chemistry, College of Science, Yazd University, Yazd 89195-741, Islamic Republic of Iran 123 1724 S. Azad, B. B. F. Mirjalili Keywords 4H-pyrimido[2,1-b]benzothiazole  Nano-TiCl /cellulose  Solid acid Supported Lewis acid  Nano-cellulose  Bio-based catalyst Introduction Benzothiazoles and their condensed system make a broader class of nitrogen and sulfur-containing compounds with a wide range of biological activities [1–11]. Among condensed benzothiazoles, pyrimido[2,1-b]benzothiazoles have attracted considerable interest because of their potent and significant pharmacological activities. A survey of the literature revealed that pyrimido[2,1-b]benzothiazoles display various biological activities like anti-tumor [12, 13], anti-allergic [14], anti-inflammatory [15], anticon- vulsant [16], antiproliferative [17], and antimicrobial activities [18–20]. In view of the importance of pyrimido[2,1-b]benzothiazoles, the development of effective strategies for the synthesis of these fused heterocyclic compounds will be interesting in both organic synthesis and medicinal chemistry. A common synthetic approach to pyrimido[2,1-b]benzothiazole derivatives involves three-component condensation of 2-amino benzothiazole, aldehydes, and b-ketoesters [21–24]. 0 0 Previously, this protocol has been catalyzed by acetic acid [13], 1,1,3,3-N,N,N ,N - tetramethylguanidinium trifluoroacetate (TMGT) [22], tetrabutylammonium hydro- gen sulfate (TBAHS) [23], N-sulfonic acid modified poly(styrene-maleic anhydride) (SMI-SO H) [26], Chitosan [24] and aluminum chloride [27]. Some Research on Chemical Intermediates Springer Journals

Nano-TiCl2/cellulose: an eco-friendly bio-based catalyst for one-pot synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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