/cellulose: an eco-friendly bio-based catalyst
for one-pot synthesis of 4H-pyrimido[2,1-
Bi Bi Fatameh Mirjalili
Received: 28 June 2016 / Accepted: 31 August 2016 / Published online: 24 September 2016
Ó Springer Science+Business Media Dordrecht 2016
Cellulose is among the most abundant natural carbon-based biopolymers con-
taining free OH groups with nucleophilic character for bonding to Lewis acids such as TiCl
/cellulose as a bio-based and eco-friendly Lewis acid catalyst was prepared via
reaction of nano-cellulose and TiCl
in dichloromethane as solvent under room temperature
conditions. This catalyst has been characterized by Fourier transform infrared spectroscopy,
ﬁeld emission scanning electron microscopy, powder X-ray diffraction, energy dispersive
X-ray spectroscopy, X-ray ﬂuorescence techniques, and transmission electron microscopy.
/cellulose has been shown to effectively promote multi-component synthesis of
4H-pyrimido[2,1-b]benzothiazole derivatives by reaction of aldehydes, b-ketoester, and
2-amino benzothiazole under thermal conditions in polyethylene glycol 400 as solvent.
Simple methodology,an eco-friendly catalyst, a clean procedure, easy work-up, and
excellent yields are some of the important advantages of this protocol.
& Bi Bi Fatameh Mirjalili
Department of Chemistry, College of Science, Yazd University, Yazd 89195-741,
Islamic Republic of Iran
Res Chem Intermed (2017) 43:1723–1734