& Bi Bi Fatameh Mirjalili firstname.lastname@example.org Department of Chemistry, College of Science, Yazd University, Yazd 89195-741, Islamic Republic of Iran 123 1724 S. Azad, B. B. F. Mirjalili Keywords 4H-pyrimido[2,1-b]benzothiazole Nano-TiCl /cellulose Solid acid Supported Lewis acid Nano-cellulose Bio-based catalyst Introduction Benzothiazoles and their condensed system make a broader class of nitrogen and sulfur-containing compounds with a wide range of biological activities [1–11]. Among condensed benzothiazoles, pyrimido[2,1-b]benzothiazoles have attracted considerable interest because of their potent and signiﬁcant pharmacological activities. A survey of the literature revealed that pyrimido[2,1-b]benzothiazoles display various biological activities like anti-tumor [12, 13], anti-allergic , anti-inﬂammatory , anticon- vulsant , antiproliferative , and antimicrobial activities [18–20]. In view of the importance of pyrimido[2,1-b]benzothiazoles, the development of effective strategies for the synthesis of these fused heterocyclic compounds will be interesting in both organic synthesis and medicinal chemistry. A common synthetic approach to pyrimido[2,1-b]benzothiazole derivatives involves three-component condensation of 2-amino benzothiazole, aldehydes, and b-ketoesters [21–24]. 0 0 Previously, this protocol has been catalyzed by acetic acid , 1,1,3,3-N,N,N ,N - tetramethylguanidinium triﬂuoroacetate (TMGT) , tetrabutylammonium hydro- gen sulfate (TBAHS) , N-sulfonic acid modiﬁed poly(styrene-maleic anhydride) (SMI-SO H) , Chitosan  and aluminum chloride . Some
Research on Chemical Intermediates – Springer Journals
Published: Sep 24, 2016
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