Electronic supplementary material The online version of this article (doi:https://doi.org/10.1007/ s11164-018-3498-6) contains supplementary material, which is available to authorized users. & Bi Bi Fatemeh Mirjalili firstname.lastname@example.org Department of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Islamic Republic of Iran 123 6420 S. A. Fazeli-Attar, B. B. F. Mirjalili Keywords Nano-Fe O @SiO –TiCl 4H-pyrimido[2,1-b]benzothiazole Solid 3 4 2 3 acid catalyst Solvent free condition Multicomponent reaction Introduction Among heterocyclic compounds, fused heterocycles showed a substantial role in pharmaceutical industry . Benzothiazole derivatives were categorized as the fused heterocycles. They have been known to have signiﬁcant applications in development of medicinal chemistry [2, 3]. To synthesis the pharmaceutical compounds, it is necessary to use a convenient and straightforward method without extra puriﬁcation. The 4H-pyrimido[2,1-b]benzothiazole derivatives are compounds with the potential ability in the preparation of drugs. In recent years, these compounds were known to be functioning as anti-tumor , anti-inﬂammatory , anti-bacterial and anti-fungal  materials. The synthesis of 4H-pyrimido[2,1- b]benzothiazole is a three-component condensation reaction between aldehyde, b- ketoester and 2-aminobenzothiazole. The catalysts including Fe O @nano-cellu- 3 4 lose-TiCl , nano-TiCl /cellulose , PdCl , C–Ti O –SO –SbCl , 2
Research on Chemical Intermediates – Springer Journals
Published: Jun 5, 2018
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