Nano-copper chromite (nano-CuCr
): a novel
and efﬁcient catalyst for the synthesis of biscoumarin
and pyrano[c]chromene derivatives in water at room
Mohammad Sadegh Moaddeli
Mohammad Reza Nazarifar
Received: 27 June 2015 / Accepted: 28 September 2015 / Published online: 26 October 2015
Ó Springer Science+Business Media Dordrecht 2015
Abstract A clean, efﬁcient and eco-friendly procedure has been developed using
nano-copper chromite (nano-CuCr
) as catalyst for the synthesis of biscoumarin
and dihydropyrano[c]chromene derivatives. This method provides several advan-
tages such as mild reaction conditions, simple work-up procedure and is environ-
ment friendly. In addition, water is chosen as a green solvent.
Keywords Dihydropyrano[c]chromenes Á Biscoumarin Á Malononitrile Á
It is known that coumarin derivatives are very useful compounds. They have been
widely used as medicine intermediates due to their useful biological and
pharmacological properties, such as anticoagulant, spasmolytic, diuretic, and
anticancer [1–4]. Biscoumarin can be employed as a urease inhibitor material .
Furthermore, dihydropyrano[3,2-c]chromenes and their derivatives are of consid-
erable interest as they possess a wide range of biological properties, such as anti-
Alzheimer’s disease, anti-AIDS-associated dementia and anti-schizophrenia .
Therefore, their synthesis has attracted much attention over the past decades.
Numerous methods have been adapted to synthesize dihydropyrano[c]chromenes
[6–14] and biscoumarin [15–19].
The use of water as a green solvent is emphasized in green chemical processes,
because of the special properties of water, such as abundance, inexpensive,
& Zahed Karimi-Jaberi
Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Fars, Iran
Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan,
P.O Box 87317-51167, Kashan, I. R. Iran
Res Chem Intermed (2016) 42:4641–4650