Nannochloropsis sp. ethanol extract prevents macrophage and LDL oxidation and enhances PON1 activity through the principal active compound lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS)

Nannochloropsis sp. ethanol extract prevents macrophage and LDL oxidation and enhances PON1... Oxidation of macrophages and low-density lipoprotein (LDL) plays a role in atherogenesis, whereas high-density lipoprotein (HDL) and its associated protein paraoxonase1 (PON1) contribute to antiatherogenic activities. Microalgae are a food source with a high content of antioxidants and omega-3 fatty acids. In this study, the potential role of extracts of the microalga Nannochloropsis sp. and isolated components in decreasing atherosclerosis risk was examined. A 70% ethanol–water extract of Nannochloropsis sp. inhibited macrophage and LDL oxidation, increased PON1 activity, and protected it from the deleterious effects of linoleic acid hydroperoxide in a dose-dependent manner. The compound responsible for increasing PON1 activity was isolated and its structure was elucidated as the (C20:5,0) lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) lipid. We suggest that the 70% ethanol–water extract of Nannochloropsis sp. has beneficial effects on decreasing atherosclerotic risk, and that the molecular structure of the active compound that increased lactonase PON1 activity was lyso-DGTS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Phycology Springer Journals

Nannochloropsis sp. ethanol extract prevents macrophage and LDL oxidation and enhances PON1 activity through the principal active compound lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS)

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media B.V., part of Springer Nature
Subject
Life Sciences; Plant Sciences; Freshwater & Marine Ecology; Plant Physiology; Ecology
ISSN
0921-8971
eISSN
1573-5176
D.O.I.
10.1007/s10811-017-1373-2
Publisher site
See Article on Publisher Site

Abstract

Oxidation of macrophages and low-density lipoprotein (LDL) plays a role in atherogenesis, whereas high-density lipoprotein (HDL) and its associated protein paraoxonase1 (PON1) contribute to antiatherogenic activities. Microalgae are a food source with a high content of antioxidants and omega-3 fatty acids. In this study, the potential role of extracts of the microalga Nannochloropsis sp. and isolated components in decreasing atherosclerosis risk was examined. A 70% ethanol–water extract of Nannochloropsis sp. inhibited macrophage and LDL oxidation, increased PON1 activity, and protected it from the deleterious effects of linoleic acid hydroperoxide in a dose-dependent manner. The compound responsible for increasing PON1 activity was isolated and its structure was elucidated as the (C20:5,0) lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) lipid. We suggest that the 70% ethanol–water extract of Nannochloropsis sp. has beneficial effects on decreasing atherosclerotic risk, and that the molecular structure of the active compound that increased lactonase PON1 activity was lyso-DGTS.

Journal

Journal of Applied PhycologySpringer Journals

Published: Dec 22, 2017

References

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