Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice

Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice Psychopharmacology (2017) 234:2747–2759 DOI 10.1007/s00213-017-4672-z ORIGINAL INVESTIGATION Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice 1,2 1 1 Laura Font & Christa A. Houck & Christopher L. Cunningham Received: 24 March 2017 /Accepted: 6 June 2017 /Published online: 26 June 2017 Springer-Verlag GmbH Germany 2017 Abstract against alteration of general learning or memory processes Rationale Previous studies found that naloxone (NLX) facil- (experiment 4). Overall, these data suggest that the endoge- itated choice extinction of ethanol conditioned place prefer- nous opioid system mediates a conditioned motivational effect ence (CPP) using long (60 min) test sessions, but there is little that normally maintains alcohol-induced seeking behavior, information on the variables determining this effect. which may underlie the efficacy of opiate antagonists in the Objectives These studies examined repeated exposure to treatment of alcoholism. NLX during extinction of ethanol- or cocaine-induced CPP using both short and long tests. . . . . Keywords Alcohol Reward Conditioning Extinction Methods DBA/2J mice were injected with NLX (0 or 10 mg/ Inbred mice (DBA/2J) kg) before three 10- or 60-min choice extinction tests (exper- iment 1). All mice received a final 60-min test without NLX. Post-test NLX was given http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4672-z
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2747–2759 DOI 10.1007/s00213-017-4672-z ORIGINAL INVESTIGATION Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice 1,2 1 1 Laura Font & Christa A. Houck & Christopher L. Cunningham Received: 24 March 2017 /Accepted: 6 June 2017 /Published online: 26 June 2017 Springer-Verlag GmbH Germany 2017 Abstract against alteration of general learning or memory processes Rationale Previous studies found that naloxone (NLX) facil- (experiment 4). Overall, these data suggest that the endoge- itated choice extinction of ethanol conditioned place prefer- nous opioid system mediates a conditioned motivational effect ence (CPP) using long (60 min) test sessions, but there is little that normally maintains alcohol-induced seeking behavior, information on the variables determining this effect. which may underlie the efficacy of opiate antagonists in the Objectives These studies examined repeated exposure to treatment of alcoholism. NLX during extinction of ethanol- or cocaine-induced CPP using both short and long tests. . . . . Keywords Alcohol Reward Conditioning Extinction Methods DBA/2J mice were injected with NLX (0 or 10 mg/ Inbred mice (DBA/2J) kg) before three 10- or 60-min choice extinction tests (exper- iment 1). All mice received a final 60-min test without NLX. Post-test NLX was given

Journal

PsychopharmacologySpringer Journals

Published: Jun 26, 2017

References

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