Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice

Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice Psychopharmacology (2017) 234:2747–2759 DOI 10.1007/s00213-017-4672-z ORIGINAL INVESTIGATION Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice 1,2 1 1 Laura Font & Christa A. Houck & Christopher L. Cunningham Received: 24 March 2017 /Accepted: 6 June 2017 /Published online: 26 June 2017 Springer-Verlag GmbH Germany 2017 Abstract against alteration of general learning or memory processes Rationale Previous studies found that naloxone (NLX) facil- (experiment 4). Overall, these data suggest that the endoge- itated choice extinction of ethanol conditioned place prefer- nous opioid system mediates a conditioned motivational effect ence (CPP) using long (60 min) test sessions, but there is little that normally maintains alcohol-induced seeking behavior, information on the variables determining this effect. which may underlie the efficacy of opiate antagonists in the Objectives These studies examined repeated exposure to treatment of alcoholism. NLX during extinction of ethanol- or cocaine-induced CPP using both short and long tests. . . . . Keywords Alcohol Reward Conditioning Extinction Methods DBA/2J mice were injected with NLX (0 or 10 mg/ Inbred mice (DBA/2J) kg) before three 10- or 60-min choice extinction tests (exper- iment 1). All mice received a final 60-min test without NLX. Post-test NLX was given http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice

Loading next page...
 
/lp/springer_journal/naloxone-effects-on-extinction-of-ethanol-and-cocaine-induced-1OzHgBs5Qr
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4672-z
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial