Cells possess multiple Ca2+ stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca2+ signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca2+ signaling mechanism and explores the implications of the apparent proliferation of Ca2+ messengers.
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2000
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