Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Rector, H. Bloomer, D. Seldin (1964)
EFFECT OF POTASSIUM DEFICIENCY ON THE REABSORPTION OF BICARBONATE IN THE PROXIMAL TUBULE OF THE RAT KIDNEY.The Journal of clinical investigation, 43
Y. Sohma, M. Gray, Y. Imai, B. Argent (2000)
HCO3− Transport in a Mathematical Model of the Pancreatic Ductal EpitheliumThe Journal of Membrane Biology, 176
Manoocher Soleimani, G. Lesoine, J. Bergman, Peter Aronson (1991)
Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles.The Journal of biological chemistry, 266 14
S. Grassl, P. Aronson (1986)
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.The Journal of biological chemistry, 261 19
P. Schultheis, L. Clarke, P. Meneton, Marian Miller, M. Soleimani, Lara Gawenis, Tara Riddle, J. Duffy, T. Doetschman, Tong Wang, G. Giebisch, P. Aronson, J. Lorenz, G. Shull (1998)
Renal and intestinal absorptive defects in mice lacking the NHE3 Na +/H+ exchangerNature Genetics, 19
N. Abuladze, I. Lee, D. Newman, J. Hwang, A. Pushkin, Ira Kurtz (1998)
Axial heterogeneity of sodium-bicarbonate cotransporter expression in the rabbit proximal tubule.American journal of physiology. Renal physiology, 274 3
H. Hulter, J. Licht, E. Bonner, R. Glynn, A. Sebastian (1980)
Effects of glucocorticoid steroids on renal and systemic acid-base metabolism.The American journal of physiology, 239 1
C. Hickman, B. Trump (1969)
2 The KidneyFish Physiology, 1
C. Burnham, M. Flagella, Zhaohui Wang, H. Amlal, G. Shull, M. Soleimani (1998)
Cloning, renal distribution, and regulation of the rat Na+-[Formula: see text]cotransporter.American journal of physiology. Renal physiology, 274 6
M. Hurtado, Bernardo Alvarez, N. Pérez, Horacio Cingolani (1996)
Role of an electrogenic Na(+)-HCO3- cotransport in determining myocardial pHi after an increase in heart rate.Circulation research, 79 4
M. Romero, P. Fong, U. Berger, M. Hediger, W. Boron (1998)
Cloning and functional expression of rNBC, an electrogenic Na+-[Formula: see text]cotransporter from rat kidney.American journal of physiology. Renal physiology, 274 2
H. Shumaker, H. Amlal, R. Frizzell, C. Ulrich, M. Soleimani (1999)
CFTR drives Na+-[Formula: see text]cotransport in pancreatic duct cells: a basis for defective[Formula: see text] secretion in CF.American journal of physiology. Cell physiology, 276 1
N. Abuladze, Mark Song, A. Pushkin, D. Newman, I. Lee, Susan Nicholas, I. Kurtz (2000)
Structural organization of the human NBC1 gene: kNBC1 is transcribed from an alternative promoter in intron 3.Gene, 251 2
W. Boron, E. Boulpaep (1983)
Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transportThe Journal of General Physiology, 81
Kenneth Wong, Insook Tabor (1985)
Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic processThe Journal of General Physiology, 86
T. Igarashi, J. Inatomi, T. Sekine, S. Cha, Y. Kanai, M. Kunimi, K. Tsukamoto, H. Satoh, M. Shimadzu, Fumiko Tozawa, Tetsuo Mori, M. Shiobara, G. Seki, H. Endou (1999)
Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalitiesNature Genetics, 23
Christopher Marino, Virginia Jeanes, W. Boron, B. Schmitt (1999)
Expression and distribution of the Na+-[Formula: see text] cotransporter in human pancreas.American journal of physiology. Gastrointestinal and liver physiology, 277 2
J. Freiberg, J. Kinsella, B. Sacktor (1982)
Glucocorticoids increase the Na+-H+ exchange and decrease the Na+ gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles.Proceedings of the National Academy of Sciences of the United States of America, 79 16
N. Abuladze, I. Lee, D. Newman, James Hwang, K. Boorer, A. Pushkin, I. Kurtz (1998)
Molecular Cloning, Chromosomal Localization, Tissue Distribution, and Functional Expression of the Human Pancreatic Sodium Bicarbonate Cotransporter*The Journal of Biological Chemistry, 273
O. Ruiz, Y. Qiu, L. Wang, J. Arruda (1995)
Regulation of the renal Na-HCO3 cotransporter: IV. Mechanisms of the stimulatory effect of angiotensin II.Journal of the American Society of Nephrology : JASN, 6 4
H. Tsuganezawa, Kazuo Kobayashi, M. Iyori, T. Araki, A. Koizumi, Shu-ichi Watanabe, Akimichi Kaneko, T. Fukao, T. Monkawa, Tadashi Yoshida, Do Kim, Y. Kanai, H. Endou, M. Hayashi, T. Saruta (2001)
A New Member of the HCO 3 − Transporter Superfamily Is an Apical Anion Exchanger of β-Intercalated Cells in the Kidney*The Journal of Biological Chemistry, 276
G. Scheele, S. Fukuoka, H. Kern, S. Freedman (1996)
Pancreatic Dysfunction in Cystic Fibrosis Occurs as a Result of Impairments in Luminal pH, Apical Trafficking of Zymogen Granule Membranes, and Solubilization of Secretory EnzymesPancreas, 12
M. Soleimani, C. Burnham (2000)
Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes.Kidney international, 57 2
I. Choi, C. Aalkjaer, E. Boulpaep, W. Boron (2000)
An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channelNature, 405
Chang-Zheng Wang, H. Yano, K. Nagashima, S. Seino (2000)
The Na+-driven Cl−/HCO3 −ExchangerThe Journal of Biological Chemistry, 275
O. Ruiz, Y. Qiu, L. Wang, J. Arruda (1996)
Regulation of the renal Na-HCO3 cotransporter: V. mechanism of the inhibitory effect of parathyroid hormone.Kidney international, 49 2
H. Hulter, J. Sigala, A. Sebastian (1981)
Effects of dexamethasone on renal and systemic acid-base metabolism.Kidney international, 20 1
M. Soleimani, G. Bizal, T. Mckinney, Y. Hattabaugh (1992)
Effect of in vitro metabolic acidosis on luminal Na+/H+ exchange and basolateral Na+:HCO3- cotransport in rabbit kidney proximal tubules.The Journal of clinical investigation, 90 1
J. Fitz, Marcello Persico, B. Scharschmidt (1989)
Electrophysiological evidence for Na+-coupled bicarbonate transport in cultured rat hepatocytes.The American journal of physiology, 256 3 Pt 1
O. Ruiz, J. Arruda (1992)
Regulation of the renal Na-HCO3 cotransporter by cAMP and Ca-dependent protein kinases.The American journal of physiology, 262 4 Pt 2
G. Capasso, R. Kinne, G. Malnic, G. Giebisch (1986)
Renal bicarbonate reabsorption in the rat. I. Effects of hypokalemia and carbonic anhydrase.The Journal of clinical investigation, 78 6
M. Shiohara, T. Igarashi, Tetsuo Mori, A. Komiyama (2000)
Genetic and long-term data on a patient with permanent isolated proximal renal tubular acidosisEuropean Journal of Pediatrics, 159
D. Lagadic-Gossmann, K. Buckler, R. Vaughan-Jones (1992)
Role of bicarbonate in pH recovery from intracellular acidosis in the guinea‐pig ventricular myocyte.The Journal of Physiology, 458
R. Kunau, A. Frick, F. Rector, D. Seldin (1968)
Micropuncture study of the proximal tubular factors responsible for the maintenance of alkalosis during potassium deficiency in the rat.Clinical science, 34 2
A. Pushkin, N. Abuladze, I. Lee, D. Newman, James Hwang, I. Kurtz (1999)
Cloning, Tissue Distribution, Genomic Organization, and Functional Characterization of NBC3, a New Member of the Sodium Bicarbonate Cotransporter Family*The Journal of Biological Chemistry, 274
T. Jentsch, T. Stahlknecht, H. Hollwede, D. Fischer, S. Keller, M. Wiederholt (1985)
A bicarbonate-dependent process inhibitable by disulfonic stilbenes and a Na+/H+ exchange mediate 22Na+ uptake into cultured bovine corneal endothelium.The Journal of biological chemistry, 260 2
T. Nagase, K. Ishikawa, M. Suyama, R. Kikuno, N. Miyajima, Ayako Tanaka, H. Kotani, N. Nomura, O. Ohara (1998)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.DNA research : an international journal for rapid publication of reports on genes and genomes, 5 5
O. Ruiz, L. Wang, Yi-Yong Qiu, Felicidad Kear, A. Bernardo, Jose Arruda (1996)
Regulation of the renal Na-HCO3 cotransporter: VI. Mechanism of the stimulatory effect of protein kinase C.Kidney international, 49 3
Christopher Sciortino, Michael Romero (1999)
Cation and voltage dependence of rat kidney electrogenic Na+-[Formula: see text]cotransporter, rkNBC, expressed in oocytes.American journal of physiology. Renal physiology, 277 4
R. Alpern (1990)
Cell mechanisms of proximal tubule acidification.Physiological reviews, 70 1
M. Romero, Darin Henry, S. Nelson, P. Harte, Alison Dillon, Christopher Sciortino (2000)
Cloning and Characterization of a Na+-driven Anion Exchanger (NDAE1)The Journal of Biological Chemistry, 275
I. Grichtchenko, I. Choi, Xiaobo Zhong, P. Bray-Ward, J. Russell, W. Boron (2001)
Cloning, Characterization, and Chromosomal Mapping of a Human Electroneutral Na+-driven Cl-HCO3Exchanger*The Journal of Biological Chemistry, 276
G. Capasso, P. Jaeger, G. Giebisch, V. Guckian, G. Malnic (1987)
Renal bicarbonate reabsorption in the rat. II. Distal tubule load dependence and effect of hypokalemia.The Journal of clinical investigation, 80 2
M. Soleimani, S. Grassi, P. Aronson (1987)
Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.The Journal of clinical investigation, 79 4
K. Ishibashi, S. Sasaki, F. Marumo (1998)
Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina.Biochemical and biophysical research communications, 246 2
A. Pushkin, K. Yip, I. Clark, N. Abuladze, T. Kwon, S. Tsuruoka, G. Schwartz, S. Nielsen, I. Kurtz (1999)
NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase.American journal of physiology. Renal physiology, 277 6
H. Amlal, K. Habo, M. Soleimani (2000)
Potassium deprivation upregulates expression of renal basolateral Na(+)-HCO(3)(-) cotransporter (NBC-1).American journal of physiology. Renal physiology, 279 3
A. Pushkin, N. Abuladze, D. Newman, I. Lee, Gouping Xu, I. Kurtz (2000)
Two C‐Terminal Variants of NBC4, a New Member of the Sodium Bicarbonate Cotransporter Family: Cloning, Characterization, and LocalizationIUBMB Life, 50
Henrik Vorum, Tae-Hwan Kwon, Christiaan Fulton, Brian Simonsen, I. Choi, W. Boron, A. Maunsbach, Søren Nielsen, Christian Aalkjaer (2000)
Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney.American journal of physiology. Renal physiology, 279 5
V. Rajendran, M. Oesterlin, H. Binder (1991)
Sodium uptake across basolateral membrane of rat distal colon. Evidence for Na-H exchange and Na-anion cotransport.The Journal of clinical investigation, 88 4
M. Soleimani, G. Singh (1995)
Physiologic and molecular aspects of the Na+/H+ exchangers in health and disease processes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 43 5
T. Akiba, V. Rocco, D. Warnock (1987)
Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis.The Journal of clinical investigation, 80 2
D. Gleeson, N. Smith, J. Boyer (1989)
Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport.The Journal of clinical investigation, 84 1
M. Romero, M. Hediger, E. Boulpaep, W. Boron (1997)
Expression cloning and characterization of a renal electrogenic Na+ /HCO3 − cotransporterNature, 387
Zhaohui Wang, Laura Conforti, S. Petrovic, H. Amlal, C. Burnham, M. Soleimani (2001)
Mouse Na+: HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution.Kidney international, 59 4
Xiang Luo, Joo Choi, S. Ko, A. Pushkin, I. Kurtz, W. Ahn, Min Lee, S. Muallem (2001)
HCO 3 − Salvage Mechanisms in the Submandibular Gland Acinar and Duct Cells*The Journal of Biological Chemistry, 276
I. Choi, M. Romero, N. Khandoudi, A. Bril, W. Boron (1999)
Cloning and characterization of a human electrogenic Na+-[Formula: see text]cotransporter isoform (hhNBC).American journal of physiology. Cell physiology, 276 3
O. Ruiz, Y. Qiu, Lucio Cardoso, Jose Arruda (1997)
Regulation of the renal Na-HCO3 cotransporter: VII. Mechanism of the cholinergic stimulation.Kidney international, 51 4
M., L. Astion, A., L. Obaid, R. Orkand (1989)
Effects of barium and bicarbonate on glial cells of Necturus optic nerve. Studies with microelectrodes and voltage-sensitive dyesThe Journal of General Physiology, 93
Michael Romero, W. Boron (1999)
Electrogenic Na+/HCO3- cotransporters: cloning and physiology.Annual review of physiology, 61
R. Lubman, D. Chao, E. Crandall (1995)
Basolateral localization of Na(+)-HCO3- cotransporter activity in alveolar epithelial cells.Respiration physiology, 100 1
M. Soleimani, J. Bergman, M Hosford, T McKinney (1990)
Potassium depletion increases luminal Na+/H+ exchange and basolateral Na+:CO3=:HCO3- cotransport in rat renal cortex.The Journal of clinical investigation, 86 4
A. Pushkin, N. Abuladze, D. Newman, I. Lee, Gouping Xu, I. Kurtz (2000)
Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.Biochimica et biophysica acta, 1493 1-2
M. Bevensee, B. Schmitt, I. Choi, Michael Romero, W. Boron (2000)
An electrogenic Na(+)-HCO(-)(3) cotransporter (NBC) with a novel COOH-terminus, cloned from rat brain.American journal of physiology. Cell physiology, 278 6
H. Ishiguro, M. Steward, R. Wilson, R. Case (1996)
Bicarbonate secretion in interlobular ducts from guinea‐pig pancreas.The Journal of Physiology, 495
L. Counillon, J. Pouysségur (2000)
The Expanding Family of Eucaryotic Na+/H+Exchangers*The Journal of Biological Chemistry, 275
H. Amlal, C. Burnham, M. Soleimani (1999)
Characterization of Na+/[Formula: see text]cotransporter isoform NBC-3.American journal of physiology. Renal physiology, 276 6
C. Burnham, H. Amlal, Zhaohui Wang, G. Shull, M. Soleimani (1997)
Cloning and Functional Expression of a Human Kidney Na+:HCO3 −Cotransporter*The Journal of Biological Chemistry, 272
R. Kopito (1990)
Molecular biology of the anion exchanger gene family.International review of cytology, 123
R. Alpern, Kenneth Wong (1985)
A Sodium-coupled Electrogenic Process
M. Soleimani, P. Aronson (1989)
Ionic mechanism of Na+-HCO3- cotransport in rabbit renal basolateral membrane vesicles.The Journal of biological chemistry, 264 31
The sodium bicarbonate cotransporter (NBC1) is essential for bicarbonate transport across plasma membranes in epithelial and nonepithelial cells. The direction of the NaHCO3 movement in secretory epithelia is opposite to that in reabsorptive epithelia. In secretory epithelia (such as pancreatic duct cells) NBC is responsible for the transport of bicarbonate from blood to the cell for eventual secretion at the apical membrane. In reabsorptive epithelia (such as kidney proximal tubule cells) NBC is responsible for the reabsorption of bicarbonate from cell to the blood. In nonepithelial cells this transporter is mainly involved with cell pH regulation. Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Na-dependent Chloride-Bicarbonate Exchanger). All but AE4 are presumed to mediate the cotransport of Na+ and HCO3 − under normal conditions and may be functionally altered in certain pathologic states. NBC1 shows a limited tissue expression pattern, is electrogenic and plays an important role in bicarbonate reabsorption in kidney proximal tubule. In addition to the kidney, NBC1 is expressed in pancreatic duct cells, is activated by cystic fibrosis transmembrane conductance regulator (CFTR) and plays an important role in HCO3 − secretion. NBC2 and NBC3 have a wider tissue distribution than NBC1, are electroneutral, and are involved with cell pH regulation. The characterization of NBC4 is incomplete. The NBC-related protein called NCBE mediates Na-dependent, Cl−/Bicarbonate Exchange. The purpose of this review is to summarize recent advances on the cloning of NBC isoforms and related proteins and their role and regulation in physiologic and pathologic states.
The Journal of Membrane Biology – Springer Journals
Published: Sep 15, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.