In this study, N-vinylcaprolactam, metacrylic acid sodium salt and itaconic acid sodium salt-based copolymeric and terpolymeric microgels were synthesized by precipitation polymerization method with 2,2′-azobis(2-methylpropioamidine) dihydrochloride as initiator. Then these microgels were characterized by SEM technique, cloud points and colloidal properties determinations. Volume phase transitions of copolymeric and terpolymeric N-vinylcaprolactam-based microgels are determined at an interval of 32–37 °C. Rhodamine B (model drug) and Nadalol (beta-blocker drug) were used to investigate the drug loading and release behavior of microgels. It is concluded that model drug loading capacity and release amount changed with the presence and amount of itaconic acid sodium salt in the microgel structure. In addition, the maximum drug release amount of microgels was found to be 58 and 55 % for Rhodamine B and Nadolol, respectively. As a result, we can say that the microgels obtained in this study are suitable for drug delivery applications.
Research on Chemical Intermediates – Springer Journals
Published: Jan 13, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera