Virologica Sinica (2018) 33:287–290 www.virosin.org https://doi.org/10.1007/s12250-018-0036-z www.springer.com/12250(0123456789().,-volV)(0123456789().,-volV) LETTER N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses 1 1 1 1 • • • Qingxiu Chen Hong Guo Fuxian Zhang Qin Fang Received: 16 March 2018 / Accepted: 10 May 2018 / Published online: 5 June 2018 Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018 Dear Editor, proteins VP5 and VP7 are homologs of the mammalian reovirus (MRV) proteins l1and r3, respectively. Further- Myristoylation is a naturally occurring post-translational more, the autocleavage of outer capsid protein VP5 at its modiﬁcation for targeting cytoplasmic proteins to intracel- N-terminus is proposed to be required for viral entry into host lular membranes. Unlike enveloped animal viruses, which cells during infection (Li and Fang 2013;Yan et al. 2015). enter host cells by membrane fusion, nonenveloped animal Similar to most animal viruses, nonenveloped reovirus viruses must disrupt the cell membrane to initiate infection. enter the host cells by a series of stepwise capsid rearrange- Some animal viruses and several nonenveloped viruses such ments or disassembly and structural changes to traverse the as reovirus and poliovirus were shown to contain myris- host membrane via the formation
Virologica Sinica – Springer Journals
Published: Jun 5, 2018
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