Russian Journal of Genetics, Vol. 38, No. 10, 2002, p. 1219. Translated from Genetika, Vol. 38, No. 10, 2002, pp. 1436–1437. Original Russian Text Copyright © 2002 by Ivanov, Ginter. BOOK REVIEWS N.P. Bochkov, Clinical Genetics: A Textbook for Students of Medical Colleges, the Second Revised Edition, Moscow: GEOTAR-MED, 2001 Four years have passed since the ﬁrst edition of only a great number of new theoretical postulates, but Clinical Genetics by N.P. Bochkov (Moscow: Medit- also the methods of their application to medical prac- sina, 1997) came out. The book was highly esteemed by tice. We would like to emphasize that the author has medical students, professors, and doctors. During this successfully solved these complicated tasks: the reader rather short period of time, genetics (especially human, can see a panorama of modern clinical genetics as an medical, and clinical genetics) has accumulated many important component of high-technology medicine. At new facts as well as theoretical concepts. The genomes the same time, the presentation of the material is of the human, mouse, and some other organisms were intended for practitioners dealing with real patients. mapped and sequenced, which laid the basis for Although the general structure of the book has genomics, a new branch of molecular genetics; the cat- remained unchanged, some chapters contain new sec- alogue of cloned genes of hereditary diseases and muta- tions that were absent in the ﬁrst edition. These are, tions of these genes was considerably extended; the e.g., a brief history of medical genetics, axioms of med- views of trans-acting mutations took shape; numerous ical genetics, genomics and clinical medicine (Chapter 1), new oncogenes and genes responsible for DNA repair, and computer software for diagnostics of hereditary detoxiﬁcation of xenobiotics, predisposition to dis- diseases (Chapter 3). The new sections supplemented eases, sensitivity–resistance–tolerance to certain phar- the text with new data obtained recently and made it maceutical agents were discovered; new methods of more complete and integral. The new chapter “Ethical molecular genetic diagnostics of diseases were devel- Problems of Medical Genetics” has also blended with oped. These are only a few examples of advances in the whole text. The facts that new medical genetic pro- these ﬁelds of genetics. cedures are more invasive and that both the patient and his (her) family are interested in some clinical genetic For the fundamental innovations in medical genetics data made the ethical aspect of clinical genetic studies to be comprehensible, their essence should be under- a topical problem. In addition, Bochkov tastefully stood in clinical perspective. For example, it is neces- included the principles of modern medical ethics (more sary to explain to students a realistic view on the role often referred to as bioethics or biomedical ethics) into and place of genetics in medicine. On the one hand, the this chapter. students should not underestimate the role of genetics. On the other hand, they should not lapse into the unjus- The didactic basis, including illustrations, diagrams, tiﬁed euphoria of “predictive medicine” and “genetic tables, test questions, reference materials, etc., of the determinism” and imagine that the era of diagnostics second edition of the Clinical Genetics […] has been and medical treatment is coming to an end, and these extended (compared to the ﬁrst edition) and revised. obsolete concepts are giving way to genotyping as the The most graphic photos of patients and illustrations of basis for precise prediction of the entire future medical individual disturbances in ontogeny, clinical signs of history of each person, irrespective of the circum- the diseases, etc. have been thoroughly selected. stances, life style, and behavior. In conclusion, note that the second edition of the Clin- ical Genetics […] by Bochkov is more comprehensive At the present time, medical students need a mod- than the ﬁrst edition and presents the subject integrally, ernized textbook on medical genetics which should with all recent achievements in the science taken into take into account all recent scientiﬁc advances, but also account. We believe that this book deserves to be regarded be free of any “populistic” overstatements. as the best Russian textbook on clinical genetics and will Bochkov has largely revised the text of the book’s undoubtedly be useful for medical students, practitioners, ﬁrst edition while preserving its general structure. In and researchers in various ﬁelds of medicine. the second edition, the factual material on the clinical signs and genetics of various hereditary diseases has been considerably extended. The book describes not V. I. Ivanov and E. K. Ginter 1022-7954/02/3810-1219$27.00 © 2002 MAIK ÒNauka / Interperiodica”
Russian Journal of Genetics – Springer Journals
Published: Oct 13, 2004
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