Eur J Nutr (2018) 57:327–338 https://doi.org/10.1007/s00394-016-1322-x ORIGINAL CONTRIBUTION N‑acetylcysteine attenuates intrauterine growth retardation‑induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis 1 1 1 1 1 1 Hao Zhang · Weipeng Su · Zhixiong Ying · Yueping Chen · Le Zhou · Yue Li · 1 1 1 Jingfei Zhang · Lili Zhang · Tian Wang Received: 14 April 2016 / Accepted: 29 September 2016 / Published online: 8 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract protein carbonyl and MDA contents were decreased in the Purpose The objective of the present study was to test the IUGR-NAC group compared with the IUGR-CON group. hypothesis that N-acetylcysteine (NAC) may play benefi - In addition, NAC-treated piglets had an increased con- cial roles against intrauterine growth retardation (IUGR)- tent of B cell lymphoma/leukemia 2 protein, whereas a induced hepatic damage in suckling piglets. decreased expression level of MAP1LC3B-II in the liver. Methods Fourteen IUGR and seven normal birth weight Conclusions NAC may have beneficial effects in improv - (NBW) neonatal male piglets were selected. Piglets were ing GSH synthesis and cellular homeostasis in the liver of weaned at 7 days of postnatal age and fed the
European Journal of Nutrition – Springer Journals
Published: Oct 8, 2016
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