N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis

N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling... Eur J Nutr (2018) 57:327–338 https://doi.org/10.1007/s00394-016-1322-x ORIGINAL CONTRIBUTION N‑acetylcysteine attenuates intrauterine growth retardation‑induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis 1 1 1 1 1 1 Hao Zhang · Weipeng Su · Zhixiong Ying · Yueping Chen · Le Zhou · Yue Li · 1 1 1 Jingfei Zhang · Lili Zhang · Tian Wang Received: 14 April 2016 / Accepted: 29 September 2016 / Published online: 8 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract protein carbonyl and MDA contents were decreased in the Purpose The objective of the present study was to test the IUGR-NAC group compared with the IUGR-CON group. hypothesis that N-acetylcysteine (NAC) may play benefi - In addition, NAC-treated piglets had an increased con- cial roles against intrauterine growth retardation (IUGR)- tent of B cell lymphoma/leukemia 2 protein, whereas a induced hepatic damage in suckling piglets. decreased expression level of MAP1LC3B-II in the liver. Methods Fourteen IUGR and seven normal birth weight Conclusions NAC may have beneficial effects in improv - (NBW) neonatal male piglets were selected. Piglets were ing GSH synthesis and cellular homeostasis in the liver of weaned at 7 days of postnatal age and fed the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nutrition Springer Journals

N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis

Loading next page...
 
/lp/springer_journal/n-acetylcysteine-attenuates-intrauterine-growth-retardation-induced-hRPVXtgHTS
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2016 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Nutrition
ISSN
1436-6207
eISSN
1436-6215
D.O.I.
10.1007/s00394-016-1322-x
Publisher site
See Article on Publisher Site

Abstract

Eur J Nutr (2018) 57:327–338 https://doi.org/10.1007/s00394-016-1322-x ORIGINAL CONTRIBUTION N‑acetylcysteine attenuates intrauterine growth retardation‑induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis 1 1 1 1 1 1 Hao Zhang · Weipeng Su · Zhixiong Ying · Yueping Chen · Le Zhou · Yue Li · 1 1 1 Jingfei Zhang · Lili Zhang · Tian Wang Received: 14 April 2016 / Accepted: 29 September 2016 / Published online: 8 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract protein carbonyl and MDA contents were decreased in the Purpose The objective of the present study was to test the IUGR-NAC group compared with the IUGR-CON group. hypothesis that N-acetylcysteine (NAC) may play benefi - In addition, NAC-treated piglets had an increased con- cial roles against intrauterine growth retardation (IUGR)- tent of B cell lymphoma/leukemia 2 protein, whereas a induced hepatic damage in suckling piglets. decreased expression level of MAP1LC3B-II in the liver. Methods Fourteen IUGR and seven normal birth weight Conclusions NAC may have beneficial effects in improv - (NBW) neonatal male piglets were selected. Piglets were ing GSH synthesis and cellular homeostasis in the liver of weaned at 7 days of postnatal age and fed the

Journal

European Journal of NutritionSpringer Journals

Published: Oct 8, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off