Eur J Nutr (2018) 57:391–403 DOI 10.1007/s00394-017-1433-z ORIGINAL CONTRIBUTION Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice 1,2 2 2 3 2,4 Tao Hu · Xiaoxue Yuan · Gang Wei · Haoshu Luo · Hyuek Jong Lee · Wanzhu Jin Received: 22 September 2016 / Accepted: 5 March 2017 / Published online: 24 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract glucose intolerance test, blood lipid profile and BAT activa- Purpose Myricetin, a dietary flavonoid, is effective in the tion using PET-CT were assessed. treatment of obesity and insulin resistance by increasing Results After myricetin treatment for 14 weeks, systemic glucose transport and lipogenesis in adipocyte and dimin- insulin resistance and hepatic steatosis were significantly ishing systemic inflammation in obesity. However, it has improved in db/db mice with body weight reduction and not been revealed yet whether myricetin is associated with myricetin led to decreased adipocity, improved plasma brown adipose tissue (BAT) activation that tightly mediates lipid profiles and increased energy expenditure. Myricetin systemic energy metabolism. Therefore, this study assessed activated BAT by upregulating thermogenic protein expres- whether myricetin activated brown adipose tissue in db/db sion and activating mitochondrial biogenesis, eventually mouse. increasing heat dissipation in skin after cold exposure. In Methods
European Journal of Nutrition – Springer Journals
Published: Apr 24, 2017
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