Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice

Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in... Eur J Nutr (2018) 57:391–403 DOI 10.1007/s00394-017-1433-z ORIGINAL CONTRIBUTION Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice 1,2 2 2 3 2,4 Tao Hu  · Xiaoxue Yuan  · Gang Wei  · Haoshu Luo  · Hyuek Jong Lee  · Wanzhu Jin   Received: 22 September 2016 / Accepted: 5 March 2017 / Published online: 24 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract glucose intolerance test, blood lipid profile and BAT activa- Purpose Myricetin, a dietary flavonoid, is effective in the tion using PET-CT were assessed. treatment of obesity and insulin resistance by increasing Results After myricetin treatment for 14 weeks, systemic glucose transport and lipogenesis in adipocyte and dimin- insulin resistance and hepatic steatosis were significantly ishing systemic inflammation in obesity. However, it has improved in db/db mice with body weight reduction and not been revealed yet whether myricetin is associated with myricetin led to decreased adipocity, improved plasma brown adipose tissue (BAT) activation that tightly mediates lipid profiles and increased energy expenditure. Myricetin systemic energy metabolism. Therefore, this study assessed activated BAT by upregulating thermogenic protein expres- whether myricetin activated brown adipose tissue in db/db sion and activating mitochondrial biogenesis, eventually mouse. increasing heat dissipation in skin after cold exposure. In Methods http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nutrition Springer Journals

Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Nutrition
ISSN
1436-6207
eISSN
1436-6215
D.O.I.
10.1007/s00394-017-1433-z
Publisher site
See Article on Publisher Site

Abstract

Eur J Nutr (2018) 57:391–403 DOI 10.1007/s00394-017-1433-z ORIGINAL CONTRIBUTION Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice 1,2 2 2 3 2,4 Tao Hu  · Xiaoxue Yuan  · Gang Wei  · Haoshu Luo  · Hyuek Jong Lee  · Wanzhu Jin   Received: 22 September 2016 / Accepted: 5 March 2017 / Published online: 24 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract glucose intolerance test, blood lipid profile and BAT activa- Purpose Myricetin, a dietary flavonoid, is effective in the tion using PET-CT were assessed. treatment of obesity and insulin resistance by increasing Results After myricetin treatment for 14 weeks, systemic glucose transport and lipogenesis in adipocyte and dimin- insulin resistance and hepatic steatosis were significantly ishing systemic inflammation in obesity. However, it has improved in db/db mice with body weight reduction and not been revealed yet whether myricetin is associated with myricetin led to decreased adipocity, improved plasma brown adipose tissue (BAT) activation that tightly mediates lipid profiles and increased energy expenditure. Myricetin systemic energy metabolism. Therefore, this study assessed activated BAT by upregulating thermogenic protein expres- whether myricetin activated brown adipose tissue in db/db sion and activating mitochondrial biogenesis, eventually mouse. increasing heat dissipation in skin after cold exposure. In Methods

Journal

European Journal of NutritionSpringer Journals

Published: Apr 24, 2017

References

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