Myeloid sarcoma of the nasal septum following invasive fungal sinusitis: report of a case and review of the relevant literature

Myeloid sarcoma of the nasal septum following invasive fungal sinusitis: report of a case and... Myeloid sarcoma is an uncommon extramedullary manifestation of myeloproliferative malignancies, such as acute myeloid leukemia (AML). This sarcoma most often involves structures such as subperiosteal bone, peritoneum, or pericardium, and has only rarely been reported in the nose and paranasal sinuses. The signs and symptoms of myeloid sarcoma can overlap with those of acute invasive fungal sinusitis (AIFS), a life-threatening surgical emergency. This report describes a 75-year-old male with a known history of AML who developed both AIFS and myeloid sarcoma. Several months after successful treatment for biopsy proven AIFS, this patient developed a new soft tissue mass of the nasal septum. A new biopsy was obtained which revealed infiltrating blast cells with evidence of monocytic differentiation diagnostic of myeloid sarcoma. Given symptoms of severe nasal obstruction, this patient received palliative radiotherapy to the nasal septum, which provided temporary improvement prior to the patient succumbing to his underlying malignancy. We review the existing reports of mucosal myeloid sarcomas, diagnostic overlap of myeloid sarcoma and AIFS, as well as currently available treatment strategies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Hematopathology Springer Journals

Myeloid sarcoma of the nasal septum following invasive fungal sinusitis: report of a case and review of the relevant literature

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Pathology; Hematology
ISSN
1868-9256
eISSN
1865-5785
D.O.I.
10.1007/s12308-018-0319-1
Publisher site
See Article on Publisher Site

Abstract

Myeloid sarcoma is an uncommon extramedullary manifestation of myeloproliferative malignancies, such as acute myeloid leukemia (AML). This sarcoma most often involves structures such as subperiosteal bone, peritoneum, or pericardium, and has only rarely been reported in the nose and paranasal sinuses. The signs and symptoms of myeloid sarcoma can overlap with those of acute invasive fungal sinusitis (AIFS), a life-threatening surgical emergency. This report describes a 75-year-old male with a known history of AML who developed both AIFS and myeloid sarcoma. Several months after successful treatment for biopsy proven AIFS, this patient developed a new soft tissue mass of the nasal septum. A new biopsy was obtained which revealed infiltrating blast cells with evidence of monocytic differentiation diagnostic of myeloid sarcoma. Given symptoms of severe nasal obstruction, this patient received palliative radiotherapy to the nasal septum, which provided temporary improvement prior to the patient succumbing to his underlying malignancy. We review the existing reports of mucosal myeloid sarcomas, diagnostic overlap of myeloid sarcoma and AIFS, as well as currently available treatment strategies.

Journal

Journal of Hematopathology – Springer Journals

Published: Mar 27, 2018

References

  • Acute myeloid leukemia
    Döhner, H; Weisdorf, DJ; Bloomfield, CD
  • Granulocytic sarcomas of the head and neck
    Alessi, DM; Karin, R; Abemayor, E; Crockett, DM
  • Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx and external acoustic meatus at relapse after high-dose cytarabine: case report and review of the literature
    Sugimoto, Y; Nishii, K; Sakakura, M; Araki, H; Usui, E; Lorenzo V, F; Hoshino, N; Miyashita, H; Ohishi, K; Katayama, N; Shiku, H
  • Maxillo-ethmoidal chloroma in acute myeloid leukaemia: case report
    Ferri, E; Minotto, C; Ianniello, F; Cavaleri, S; Armato, E; Capuzzo, P
  • Intraoral granulocytic sarcoma presenting as multiple maxillary and mandibular masses: a case report and literature review
    Xie, Z; Zhang, F; Song, E; Ge, W; Zhu, F; Hu, J
  • Granulocytic sarcoma of the nasal cavity: a case report
    Gorman, M; Ahmed, KA; Pallera, A; Samant, S
  • Myeloid sarcoma mimicking nasopharyngeal carcinoma
    Cho, SF; Liu, YC; Tsai, HJ; Lin, SF
  • Unusual coexistence of sinonasal myeloid sarcoma and acute fulminant invasive fungal sinusitis: a diagnostic dilemma
    Kuo, CL; Yu, YB; Li, WY; Lee, YL
  • Myeloid sarcoma of the cheek and the maxillary sinus regions
    Mei, KD; Lin, YS; Chang, SL
  • Myeloid sarcomas of the head and neck in pediatric patients with myeloid leukemia
    Cuthbertson, DW; Punia, JN; Owczarzak, VL
  • Acute invasive fungal rhinosinusitis: a 15-year experience with 41 patients
    Payne, SJ; Mitzner, R; Kunchala, S; Roland, L; Mcginn, JD
  • Leukemia cutis
    Cho-Vega, JH; Medeiros, LJ; Prieto, VG; Vega, F
  • A comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis
    Agis, H; Weltermann, A; Fonatsch, C; Haas, O; Mitterbauer, G; Müllauer, L; Schreiber, S; Schwarzinger, I; Juretzka, W; Valent, P; Jäger, U; Lechner, K; Geissler, K
  • Histologically proven leukemia cutis carries a poor prognosis in acute nonlymphocytic leukemia
    Shaikh, BS; Frantz, E; Lookingbill, DP
  • Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria
    Kaddu, S; Zenahlik, P; Beham-Schmid, C; Kerl, H; Cerroni, L
  • Acutemyelomonocytic leukemia presenting as a benign-appearing cutaneous eruption
    Horlick, HP; Silvers, DN; Knobler, EH; Cole, JT
  • Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases
    Nieman, RS; Barcos, M; Berard, C
  • An immunohistochemical and clinicopathological study of granulocytic sarcoma (‘chloroma’)
    Muller, S; Sangster, G; Crocker, J
  • Oral manifestations of acute myelomonocytic leukemia: a case report and review of the classification of leukemias
    Wu, J; Fantasia, JE; Kaplan, R
  • Granulocytic sarcoma in childhood leukemia: imaging feature
    Pui, MH; Fletcher, BD; Langston, JW
  • Radiation therapy for chloroma (granulocytic sarcoma)
    Bakst, R; Wolden, S; Yahalom, J
  • Clinicopathologic features and responses to radiotherapy of myeloid sarcoma
    Chen, WY; Wang, CW; Chang, CH; Liu, HH; Lan, KH; Tang, JL; Tien, HF; Kuo, SH; Cheng, AL
  • Treatment outcomes for patients with chloroma receiving radiation therapy
    Hall, MD; Chen, YJ; Schultheiss, TE; Pezner, RD; Stein, AS; Wong, JY

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