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Mycophenolate mofetil/prednisolone/tacrolimus

Mycophenolate mofetil/prednisolone/tacrolimus Reactions 1704, p272 - 2 Jun 2018 Mycophenolate mofetil/prednisolone/ tacrolimus Cerebral toxoplasmosis and associated complications: case report A 72-year-old man developed cerebral toxoplasmosis, necrosis of brain tissue, ataxia, urinary incontinence and septic shock during treatment with tacrolimus, mycophenolate mofetil [Cellcept] and prednisolone [dosages, routes and durations of treatments to reactions onsets not stated]. The man who had undergone right kidney transplantation, was transferred to the hospital due to urinary incontinence and ataxia for about 3 weeks. He was receiving treatment with prednisolone, tacrolimus and mycophenolate mofetil. A physical examination was significant for a pulse rate of 78 /min, temperature 36°C, BP of 112/86mm Hg, respiratory rate of 20 /min. Laboratory testing showed normocytic anaemia and leucocytosis. A brain MRI scan revealed at least four lobulated nodular lesions over both right and frontal temporal lobes with marked perifocal oedema and rim- enhancement. He was admitted and a stereotactic brain biopsy was performed, which demonstrated necrosis of the brain tissue with a few macrophages, neutrophils and nuclear debris. The biopsy tissue was negative for acid fast stain and bacterial culture. Nocardiosis, toxoplasmosis or other fungal infection was suspected due to chronic immunosuppression for right kidney transplantation. Paired Toxoplasma immunoglobulin G and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Mycophenolate mofetil/prednisolone/tacrolimus

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018

Mycophenolate mofetil/prednisolone/tacrolimus

Abstract

Reactions 1704, p272 - 2 Jun 2018 Mycophenolate mofetil/prednisolone/ tacrolimus Cerebral toxoplasmosis and associated complications: case report A 72-year-old man developed cerebral toxoplasmosis, necrosis of brain tissue, ataxia, urinary incontinence and septic shock during treatment with tacrolimus, mycophenolate mofetil [Cellcept] and prednisolone [dosages, routes and durations of treatments to reactions onsets not stated]. The man who had undergone right kidney transplantation, was...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46915-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p272 - 2 Jun 2018 Mycophenolate mofetil/prednisolone/ tacrolimus Cerebral toxoplasmosis and associated complications: case report A 72-year-old man developed cerebral toxoplasmosis, necrosis of brain tissue, ataxia, urinary incontinence and septic shock during treatment with tacrolimus, mycophenolate mofetil [Cellcept] and prednisolone [dosages, routes and durations of treatments to reactions onsets not stated]. The man who had undergone right kidney transplantation, was transferred to the hospital due to urinary incontinence and ataxia for about 3 weeks. He was receiving treatment with prednisolone, tacrolimus and mycophenolate mofetil. A physical examination was significant for a pulse rate of 78 /min, temperature 36°C, BP of 112/86mm Hg, respiratory rate of 20 /min. Laboratory testing showed normocytic anaemia and leucocytosis. A brain MRI scan revealed at least four lobulated nodular lesions over both right and frontal temporal lobes with marked perifocal oedema and rim- enhancement. He was admitted and a stereotactic brain biopsy was performed, which demonstrated necrosis of the brain tissue with a few macrophages, neutrophils and nuclear debris. The biopsy tissue was negative for acid fast stain and bacterial culture. Nocardiosis, toxoplasmosis or other fungal infection was suspected due to chronic immunosuppression for right kidney transplantation. Paired Toxoplasma immunoglobulin G and

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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