Mammalian Genome 11, 1154–1156 (2000). DOI: 10.1007/s003350010198 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 mVH1, a dual-specificity phosphatase whose expression is cell cycle regulated Xin-Min Zhang, Shane P. Dormady, Wenren Chaung, Ross S. Basch Department of Pathology and the Kaplan Comprehensive Cancer Center, 550 First Avenue, New York University School of Medicine, New York, New York 10016, USA Received: 2 May 2000 / Accepted: 28 July 2000 Phosphorylation plays an importnt role in regulating many cellular genome (Hunter 1995). Cloning of these genes will provide insight processes such as cell growth, differentiation, and migration. Phos- into their roles in mammalian cell functions. phorylation is reversibly controlled by protein kinases and protein The first eukaryotic member of the family, yVH1, was cloned phsophatases (Hunter 1995). Althought the importance of protein from Saccharomyces cerevisiae by searching the yeast genome for kinases in regulating cellular activity has been well studied, less is vaccinia VH1 homologs (Guan et al. 1992). The yeast phosphatase known about protein phosphatases. Recently, a new family of is related to the Schizosaccharomyces pombe cdc25 gene product dual-specificity protein phsophatases (dsPTPs) has been identified, and to a protein encoded by a mammalian open reading frame which can
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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