Archives of Gynecology and Obstetrics (2018) 297:1067–1068 https://doi.org/10.1007/s00404-018-4705-9 CORRESPONDENCE Mutual exclusion of CDH1 and BRCA germline mutations in the pathway of hereditary breast cancer 1 2 1,3 1 G. Corso · B. Bonanni · P. Veronesi · V. Galimberti Received: 12 October 2017 / Accepted: 18 January 2018 / Published online: 3 February 2018 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Dear Editor, In this study, unaffected individual carrying S838G CDH1 germline missense mutation and BRCA negative We read with interest the recent results reported by Stuebs (CDH1+/BRCA −) seems to fulfill a different inherited et al. . The authors described novel CDH1 germline breast/ovarian cancer syndrome that requires particular alterations in families, apparently not fulfilling the canoni - attention for clinical management. cal clinical criteria established for the Hereditary Diffuse In accordance with the recent literature data, periodic Gastric Cancer (HDGC) syndrome . In particular, in this breast surveillance is required since prophylactic bilateral study, segregation for gastric tumors is rather rare or absent; mastectomy is not indicated . Whenever confirmed the conversely, a high frequency of ovarian and/or breast can- S838G pathogenicity, prophylactic total gastrectomy could cer (BC) was observed. CDH1 genetic screening of 97 BC be considered , also in the absence of
Archives of Gynecology and Obstetrics – Springer Journals
Published: Feb 3, 2018
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