Mutliaberrant cell formation caused by exposure to internal densely-ionizing irradiation

Mutliaberrant cell formation caused by exposure to internal densely-ionizing irradiation The origin of multiaberrant cells (MACs) was studied by comparing the structure and intensity of chromosome damage in peripheral blood lymphocytes of two groups of people: workers of Siberian Chemical Plant differing in the content of plutonium-239 in their bodies, and inhabitants of a non-polluted settlement (control group). Plutonium-239 is known to be a long-lived densely-ionizing source of α-radiation with high linear energy delivery; therefore, it has a stronger effect on cell hereditary structures than γ-rays. In persons with the content of plutonium-239 higher than 13 nCu, the frequency of MAC was 0.105% which at least tenfold exceeds the spontaneous level. The chromosome-type aberrations that are usually induced by ionizing radiation predominated in MACs. Our results suggest that MAC formation may be caused by internal body irradiation with the incorporated sources of densely-ionizing radiation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Mutliaberrant cell formation caused by exposure to internal densely-ionizing irradiation

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Publisher
Nauka/Interperiodica
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics; Microbial Genetics and Genomics; Animal Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1007/s11177-005-0014-z
Publisher site
See Article on Publisher Site

Abstract

The origin of multiaberrant cells (MACs) was studied by comparing the structure and intensity of chromosome damage in peripheral blood lymphocytes of two groups of people: workers of Siberian Chemical Plant differing in the content of plutonium-239 in their bodies, and inhabitants of a non-polluted settlement (control group). Plutonium-239 is known to be a long-lived densely-ionizing source of α-radiation with high linear energy delivery; therefore, it has a stronger effect on cell hereditary structures than γ-rays. In persons with the content of plutonium-239 higher than 13 nCu, the frequency of MAC was 0.105% which at least tenfold exceeds the spontaneous level. The chromosome-type aberrations that are usually induced by ionizing radiation predominated in MACs. Our results suggest that MAC formation may be caused by internal body irradiation with the incorporated sources of densely-ionizing radiation.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Feb 16, 2005

References

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