Mutation Indy p115 Extends Life Span in Adult Drosophila melanogaster Depending on Sex and Genetic Background

Mutation Indy p115 Extends Life Span in Adult Drosophila melanogaster Depending on Sex and... The Indy p115 allele in heterozygous state almost doubles the life span of adult Drosophila melanogaster, and this effect largely depends on the strain used for obtaining heterozygotes. Male and female life span depends on Indy p115 to a different degree. Apart from Indy p115 heterozygotes, sexual dimorphism for life span was also observed in strain Hikone-AW, but not in Oregon R and TM3 balancer. In heterozygotes Indy p115/OR, both the average life span and female reproductive period increased as compared to OR control. No substantial increase in female reproductive period in Indy p115/Hk heterozygotes was found. In homozygotes for allele Indy p115, we have previously revealed two phases of embryotic lethality and lethality at the larval and pupa stages. Thus, allele Indy p115 has a double and opposite effect on Drosophilaviability. On the one hand, it extends the life span of adult flies, on the other, decreases survival at preimaginal stages. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Mutation Indy p115 Extends Life Span in Adult Drosophila melanogaster Depending on Sex and Genetic Background

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/B:RUGE.0000024975.96061.e1
Publisher site
See Article on Publisher Site

Abstract

The Indy p115 allele in heterozygous state almost doubles the life span of adult Drosophila melanogaster, and this effect largely depends on the strain used for obtaining heterozygotes. Male and female life span depends on Indy p115 to a different degree. Apart from Indy p115 heterozygotes, sexual dimorphism for life span was also observed in strain Hikone-AW, but not in Oregon R and TM3 balancer. In heterozygotes Indy p115/OR, both the average life span and female reproductive period increased as compared to OR control. No substantial increase in female reproductive period in Indy p115/Hk heterozygotes was found. In homozygotes for allele Indy p115, we have previously revealed two phases of embryotic lethality and lethality at the larval and pupa stages. Thus, allele Indy p115 has a double and opposite effect on Drosophilaviability. On the one hand, it extends the life span of adult flies, on the other, decreases survival at preimaginal stages.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 18, 2004

References

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