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J. Membrane Biol. 185, 145–155 (2002) DOI: 10.1007/s00232-001-0122-1 Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels F.J.P. Ku¨ hn, N.G. Greeff Physiologisches Institut, Universita¨ tZurich, Winterthurerstr. 190, CH-8057Zu rich, Switzerland ¨ ¨ Received: 22 May 2001/Revised: 29 September 2001 Abstract. Rat brain (rBIIA) sodium channel fast in- changing the permeation properties of the channels activation kinetics and the time course of recovery of (Chahine et al., 1994; McPhee et al., 1998). the immobilized gating charge were compared for However, recent studies suggest a functional wild type (WT) and the pore mutant D384N hetero- coupling between gating and permeation (Tomaselli logously expressed in Xenopus oocytes with or with- et al., 1995; Balser et al., 1996; Wang & Wang, 1997; out the accessory b -subunit. In the absence of the b - Townsend & Horn, 1999; Be´ nitah et al., 1999; Vilin et 1 1 subunit, WT and D384N showed characteristic bi- al., 1999). For instance, Tomaselli et al. (1995) have modal inactivation kinetics, but with the fast gating demonstrated that the single point mutation W402C mode significantly more pronounced in D384N. in the P-loop of domain 1 of the l1 sodium channel Both,
The Journal of Membrane Biology – Springer Journals
Published: Jan 5, 2002
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