Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels

Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels J. Membrane Biol. 185, 145–155 (2002) DOI: 10.1007/s00232-001-0122-1 Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels F.J.P. Ku¨ hn, N.G. Greeff Physiologisches Institut, Universita¨ tZurich, Winterthurerstr. 190, CH-8057Zu rich, Switzerland ¨ ¨ Received: 22 May 2001/Revised: 29 September 2001 Abstract. Rat brain (rBIIA) sodium channel fast in- changing the permeation properties of the channels activation kinetics and the time course of recovery of (Chahine et al., 1994; McPhee et al., 1998). the immobilized gating charge were compared for However, recent studies suggest a functional wild type (WT) and the pore mutant D384N hetero- coupling between gating and permeation (Tomaselli logously expressed in Xenopus oocytes with or with- et al., 1995; Balser et al., 1996; Wang & Wang, 1997; out the accessory b -subunit. In the absence of the b - Townsend & Horn, 1999; Be´ nitah et al., 1999; Vilin et 1 1 subunit, WT and D384N showed characteristic bi- al., 1999). For instance, Tomaselli et al. (1995) have modal inactivation kinetics, but with the fast gating demonstrated that the single point mutation W402C mode significantly more pronounced in D384N. in the P-loop of domain 1 of the l1 sodium channel Both, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels

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Publisher
Springer-Verlag
Copyright
Copyright © 2002 by Springer-Verlag New York Inc.
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0122-1
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 185, 145–155 (2002) DOI: 10.1007/s00232-001-0122-1 Mutation D384N Alters Recovery of the Immobilized Gating Charge in Rat Brain IIA Sodium Channels F.J.P. Ku¨ hn, N.G. Greeff Physiologisches Institut, Universita¨ tZurich, Winterthurerstr. 190, CH-8057Zu rich, Switzerland ¨ ¨ Received: 22 May 2001/Revised: 29 September 2001 Abstract. Rat brain (rBIIA) sodium channel fast in- changing the permeation properties of the channels activation kinetics and the time course of recovery of (Chahine et al., 1994; McPhee et al., 1998). the immobilized gating charge were compared for However, recent studies suggest a functional wild type (WT) and the pore mutant D384N hetero- coupling between gating and permeation (Tomaselli logously expressed in Xenopus oocytes with or with- et al., 1995; Balser et al., 1996; Wang & Wang, 1997; out the accessory b -subunit. In the absence of the b - Townsend & Horn, 1999; Be´ nitah et al., 1999; Vilin et 1 1 subunit, WT and D384N showed characteristic bi- al., 1999). For instance, Tomaselli et al. (1995) have modal inactivation kinetics, but with the fast gating demonstrated that the single point mutation W402C mode significantly more pronounced in D384N. in the P-loop of domain 1 of the l1 sodium channel Both,

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jan 5, 2002

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