Mammalian Genome 11, 603–607 (2000). DOI: 10.1007/s003350010115 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Muta-genetics or muta-genomics: the feasibility of large-scale mutagenesis and phenotyping programs Joseph H. Nadeau Department of Genetics, BRB-630, Case Western Reserve University School of Medicine; Center for Human Genetics, University Hospitals of Cleveland, 10900 Euclid Ave., Cleveland, Ohio 44106, USA Received: 16 December 1999 / Accepted: 17 December 1999 As the first phase of the Human Genome Project approaches These mutagenized mice are, therefore, a potentially rich resource completion, attention shifts from questions of genome structure to of new models of human disease if comprehensive phenotyping problems of gene function. Gene maps and DNA sequences appear programs can be efficiently assembled. at an exponential rate in public databases for humans, mice, and An important question is whether large-scale mutagenesis and other species. Within several years, the sequence of the human, phenotyping are feasible, efficient, economical, and productive. mouse, and many other genomes is expected to be complete. The Can modest-scale studies become large-scale surveys just as cer- emerging challenge will then be to assign functions to the esti- tain aspects of genetics have been scaled for genomics? Can a mated 100,000 genes in
Mammalian Genome – Springer Journals
Published: Feb 25, 2014
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