Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes

Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes Cytotechnology https://doi.org/10.1007/s10616-018-0229-1 SHORT COMMUNICATION Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes . . . . Zhao Chong Haruka Matsuo Mai Kuroda Shuntaro Yamashita . . . Gopal Prasad Parajuli Hira Kaji Manandhar Kuniyoshi Shimizu Yoshinori Katakura Received: 1 April 2018 / Accepted: 22 May 2018 Springer Science+Business Media B.V., part of Springer Nature 2018 Abstract Mushrooms possess various bioactivities induced cellular senescence in HaCaT cells, as and are used as nutritional supplements and medicinal evidenced by increased activity and expression of products. Twenty-nine bioactive components have cellular senescence markers including senescence- been extracted recently from mushrooms grown in associated b-galactosidase, p21, p16, phosphorylated Nepal. In this study, we evaluated the ability of these p38, and cH2AX. Results clearly showed that the mushroom extracts to augment SIRT1, a mammalian mushroom extract (No. 28) suppressed the ultraviolet SIR2 homologue localized in cytosol and nuclei. We B irradiation-induced cellular senescence in HaCaT established a system for screening food ingredients cells possibly through augmenting SIRT1 expression. that augment the SIRT1 promoter in HaCaT cells, and identified a SIRT1-augmenting mushroom extract Keywords SIRT1  Mushroom  Cellular (number 28, Trametes versicolor). UVB irradiation senescence  Keratinocytes  Skin  Ultraviolet B http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytotechnology Springer Journals

Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes

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Publisher
Springer Netherlands
Copyright
Copyright © 2018 by Springer Science+Business Media B.V., part of Springer Nature
Subject
Chemistry; Biotechnology; Biomedicine, general; Biochemistry, general
ISSN
0920-9069
eISSN
1573-0778
D.O.I.
10.1007/s10616-018-0229-1
Publisher site
See Article on Publisher Site

Abstract

Cytotechnology https://doi.org/10.1007/s10616-018-0229-1 SHORT COMMUNICATION Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes . . . . Zhao Chong Haruka Matsuo Mai Kuroda Shuntaro Yamashita . . . Gopal Prasad Parajuli Hira Kaji Manandhar Kuniyoshi Shimizu Yoshinori Katakura Received: 1 April 2018 / Accepted: 22 May 2018 Springer Science+Business Media B.V., part of Springer Nature 2018 Abstract Mushrooms possess various bioactivities induced cellular senescence in HaCaT cells, as and are used as nutritional supplements and medicinal evidenced by increased activity and expression of products. Twenty-nine bioactive components have cellular senescence markers including senescence- been extracted recently from mushrooms grown in associated b-galactosidase, p21, p16, phosphorylated Nepal. In this study, we evaluated the ability of these p38, and cH2AX. Results clearly showed that the mushroom extracts to augment SIRT1, a mammalian mushroom extract (No. 28) suppressed the ultraviolet SIR2 homologue localized in cytosol and nuclei. We B irradiation-induced cellular senescence in HaCaT established a system for screening food ingredients cells possibly through augmenting SIRT1 expression. that augment the SIRT1 promoter in HaCaT cells, and identified a SIRT1-augmenting mushroom extract Keywords SIRT1  Mushroom  Cellular (number 28, Trametes versicolor). UVB irradiation senescence  Keratinocytes  Skin  Ultraviolet B

Journal

CytotechnologySpringer Journals

Published: Jun 2, 2018

References

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