Murine endogenous retroviruses and their transcriptional potentials 1,2 2 1,2 3,4 Jerry Boonyaratanakornkit, Alex Chew, Dewey D.Y. Ryu, David G. Greenhalgh, 3,4 Kiho Cho Biochemistry and Molecular Biology Graduate Group, University of California at Davis, Davis, California 95616, USA Department of Chemical Engineering and Material Sciences, University of California at Davis, Davis, California 95616, USA Department of Surgery, University of California at Davis, Sacramento, California 95817, USA Shriners Hospitals for Children Northern California, Sacramento, California 95817, USA Received: 19 April 2004 / Accepted: 13 July 2004 Viral transcripts from endogenous retroviruses ruption (Lower 1999), (2), intronic insertion of the (ERVs) have been detected from patients with mul- ERV can produce alternative splicing (Hatada et al. tiple sclerosis, breast cancer, leukemia, and schizo- 2003), and (3) viral promoter, silencer, and enhancer phrenia (Karlsson et al. 2001; Depil et al. 2002; Portis regions within the U3 region of the long terminal 2002; Wang-Johanning et al. 2003). While it is un- repeat (LTR) can affect transcription in neighboring known whether the presence of the viral transcripts genes (Ting et al. 1992; Dunn et al. 2003). The two implicates ERVs in the pathological response, ERVs flanking LTRs of the ERV contain U3 sequences
Mammalian Genome – Springer Journals
Published: Jan 1, 2004
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