Mammalian Genome 11, 938–940 (2000). DOI: 10.1007/s003350010192 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Multiple recombination events near the 3* boundary of the human IgH locus duplication Edward E. Max, Mary Mitchell, Frederick C. Mills Center for Biologics Evaluation and Research, FDA, HFM-541, Building 29A, Room 2B09, 8800 Rockville Pike, Bethesda, Maryland 20892, USA Received: 22 February 2000 / Accepted: 5 April 2000 The human immunoglobulin heavy chain constant region (IgH) locus appears to have undergone a duplication sometime during primate evolution, so that a block of human IgH genes including the Cg3-Cg1-pseudo Ce-Ca1 sequences (here designated the A1 block) lies upstream of a homologous block containing Cg2-Cg4- Ce-Ca2 (designated A2) (See Fig. 1, upper map; Flanagan and Rabbitts 1982; Hofker et al. 1989). A processed pseudogene de- rived from the elk-1 gene lies near the 38 end of each duplicated block (celk-2.1 in the A1 block and celk-2.2 in A2; Sadhu et al. 1997; Harindranath et al. 1998). Southern blot evidence suggests that both the celk insertion and the large locus duplication oc- curred after the lineage divergence between New and Old World monkeys (Harindranath et al. 1998). An additional duplication generated the cg gene (Takahashi
Mammalian Genome – Springer Journals
Published: Feb 27, 2014
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