Multiple recombination events near the 3′ boundary of the human IgH locus duplication

Multiple recombination events near the 3′ boundary of the human IgH locus duplication Mammalian Genome 11, 938–940 (2000). DOI: 10.1007/s003350010192 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Multiple recombination events near the 3* boundary of the human IgH locus duplication Edward E. Max, Mary Mitchell, Frederick C. Mills Center for Biologics Evaluation and Research, FDA, HFM-541, Building 29A, Room 2B09, 8800 Rockville Pike, Bethesda, Maryland 20892, USA Received: 22 February 2000 / Accepted: 5 April 2000 The human immunoglobulin heavy chain constant region (IgH) locus appears to have undergone a duplication sometime during primate evolution, so that a block of human IgH genes including the Cg3-Cg1-pseudo Ce-Ca1 sequences (here designated the A1 block) lies upstream of a homologous block containing Cg2-Cg4- Ce-Ca2 (designated A2) (See Fig. 1, upper map; Flanagan and Rabbitts 1982; Hofker et al. 1989). A processed pseudogene de- rived from the elk-1 gene lies near the 38 end of each duplicated block (celk-2.1 in the A1 block and celk-2.2 in A2; Sadhu et al. 1997; Harindranath et al. 1998). Southern blot evidence suggests that both the celk insertion and the large locus duplication oc- curred after the lineage divergence between New and Old World monkeys (Harindranath et al. 1998). An additional duplication generated the cg gene (Takahashi Mammalian Genome Springer Journals

Multiple recombination events near the 3′ boundary of the human IgH locus duplication

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Copyright © 2000 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Anatomy; Zoology
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