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Multiple drugs

Multiple drugs Reactions 1704, p254 - 2 Jun 2018 Disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin: case report A 45-year-old man developed fatal disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin during treatment with cyclophosphamide, vincristine, cytarabine, doxorubicin, dexamethasone, folinic acid, methotrexate and methylprednisolone [dosages and durations of treatments to reactions onsets not stated; not all routes stated]. The man was diagnosed with T-cell acute lymphoblastic leukaemia in October 2016. He started receiving treatment with hyper-CVAD regimen consisting of cyclophosphamide, intrathecal cytarabine, vincristine, doxorubicin, dexamethasone, folinic acid, methotrexate and methylprednisolone. Additionally, he received prophylactic treatment with fluconazole. He completed the first cycle of hyper-CVAD regimen. Subsequently, the treatment was complicated by a line-related bloodstream infection and intermittent confusion. A brain MRI revealed ring-enhancing lesions. CT scan of the thorax revealed nodules and cavitation. The man started receiving empiric treatment with ceftriaxone and his fluconazole prophylaxis was switched to posaconazole. The findings of brain biopsy, lumbar puncture and bronchoalveolar lavage did not led to any diagnosis. Three weeks later, a repeat CT scan of the thorax and MRI of the brain revealed improvement of the lesions. Subsequently, he received second cycle of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Multiple drugs

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Multiple drugs

Abstract

Reactions 1704, p254 - 2 Jun 2018 Disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin: case report A 45-year-old man developed fatal disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin during treatment with cyclophosphamide, vincristine, cytarabine, doxorubicin, dexamethasone, folinic acid, methotrexate and methylprednisolone [dosages and durations of treatments to reactions onsets not...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46897-z
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p254 - 2 Jun 2018 Disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin: case report A 45-year-old man developed fatal disseminated line-related bloodstream Volvariella volvacea infection involving the brain, lung and skin during treatment with cyclophosphamide, vincristine, cytarabine, doxorubicin, dexamethasone, folinic acid, methotrexate and methylprednisolone [dosages and durations of treatments to reactions onsets not stated; not all routes stated]. The man was diagnosed with T-cell acute lymphoblastic leukaemia in October 2016. He started receiving treatment with hyper-CVAD regimen consisting of cyclophosphamide, intrathecal cytarabine, vincristine, doxorubicin, dexamethasone, folinic acid, methotrexate and methylprednisolone. Additionally, he received prophylactic treatment with fluconazole. He completed the first cycle of hyper-CVAD regimen. Subsequently, the treatment was complicated by a line-related bloodstream infection and intermittent confusion. A brain MRI revealed ring-enhancing lesions. CT scan of the thorax revealed nodules and cavitation. The man started receiving empiric treatment with ceftriaxone and his fluconazole prophylaxis was switched to posaconazole. The findings of brain biopsy, lumbar puncture and bronchoalveolar lavage did not led to any diagnosis. Three weeks later, a repeat CT scan of the thorax and MRI of the brain revealed improvement of the lesions. Subsequently, he received second cycle of the

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Reactions Weekly – Springer Journals

Published: Jun 2, 2018

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