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Multiple drugs

Multiple drugs Reactions 1680, p244 - 2 Dec 2017 X S Various toxicities: case report A 72-year-old woman experienced nodding (which was further worsened due to pregabalin), extreme constipation, hyperhidrosis, obstructive sleep apnoea and delayed gastric emptying of acid (acid dyspepsia was due to diclofenac and aspirin) during treatment with fentanyl, and renal impairment during treatment with diclofenac. Further, she developed opioid withdrawal symptoms during the concomitant administration of atorvastatin, naloxegol and lansoprazole [not all routes stated; duration of treatments to reaction onsets not stated]. The woman, who was wheel chair bound, had a history of multiple degenerative painful changes in her back. She was experiencing extreme pain of her left limb including hip, knee and thigh region. She was also diagnosed with compartment syndrome. She presented to hospital with nodding (feeling of sleepiness after few minutes of conversation), severe constipation and hyperhidrosis. Prior to the presentation, she had been prescribed transdermal fentanyl patches 100 µg/h, pregabalin 450 mg/day (for her back and knee pain) and diclofenac 50mg thrice a day for pain relief, lansoprazole 30mg twice daily (control acid dyspepsia), and atorvastatin 40 mg/day (for cholesterol reduction). Additionally, after a carotid artery stenosis operation, she had been receiving aspirin [acetylsalicylic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Multiple drugs

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Multiple drugs

Abstract

Reactions 1680, p244 - 2 Dec 2017 X S Various toxicities: case report A 72-year-old woman experienced nodding (which was further worsened due to pregabalin), extreme constipation, hyperhidrosis, obstructive sleep apnoea and delayed gastric emptying of acid (acid dyspepsia was due to diclofenac and aspirin) during treatment with fentanyl, and renal impairment during treatment with diclofenac. Further, she developed opioid withdrawal symptoms during the concomitant administration of...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-39175-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p244 - 2 Dec 2017 X S Various toxicities: case report A 72-year-old woman experienced nodding (which was further worsened due to pregabalin), extreme constipation, hyperhidrosis, obstructive sleep apnoea and delayed gastric emptying of acid (acid dyspepsia was due to diclofenac and aspirin) during treatment with fentanyl, and renal impairment during treatment with diclofenac. Further, she developed opioid withdrawal symptoms during the concomitant administration of atorvastatin, naloxegol and lansoprazole [not all routes stated; duration of treatments to reaction onsets not stated]. The woman, who was wheel chair bound, had a history of multiple degenerative painful changes in her back. She was experiencing extreme pain of her left limb including hip, knee and thigh region. She was also diagnosed with compartment syndrome. She presented to hospital with nodding (feeling of sleepiness after few minutes of conversation), severe constipation and hyperhidrosis. Prior to the presentation, she had been prescribed transdermal fentanyl patches 100 µg/h, pregabalin 450 mg/day (for her back and knee pain) and diclofenac 50mg thrice a day for pain relief, lansoprazole 30mg twice daily (control acid dyspepsia), and atorvastatin 40 mg/day (for cholesterol reduction). Additionally, after a carotid artery stenosis operation, she had been receiving aspirin [acetylsalicylic

Journal

Reactions Weekly – Springer Journals

Published: Dec 2, 2017

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