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Multiple drugs

Multiple drugs Reactions 1704, p261 - 2 Jun 2018 O S Various toxicities: 10 case reports A case report originating from the centre of evaluation and information on pharmacodependence-addictovigilance of Paris described ten patients (seven men and three women), aged 25 84 years, who developed dependence to mephenesin; most of these patients were abusing mephenesin at an overdose. Four of ten patients also developed dependence to alprazolam, zolpidem, promethazine, doxylamine, codeine or bromazepam. Three of ten patients developed sleep disorder, anxiety, agitation, tremor or irritability following the withdrawal of mephenesin [routes, durations of treatments to reaction onsets and outcomes not stated, not all dosages and indication stated]. The patients had a history of depression, alcoholism, high BP, chronic obstructive pulmonary disease, fractured collarbone, capsulitis, sleep disorder, lumbar pain, childhood maltreatment, discal hernia, arthrosis, scoliosis, eating disorders, medication overuse headache, back pain or physical disability. Additionally, in six of the 10 patients, history was significant for alcoholism, overweight, gambling, illicit drugs use, alcohol abuse or cannabis use. The social history was significant for only tobacco (three patients), only alcohol (one patient) and both alcohol and tobacco (two patients). Seven of the ten patients were also receiving current medications. All the patients received http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Multiple drugs

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Multiple drugs

Abstract

Reactions 1704, p261 - 2 Jun 2018 O S Various toxicities: 10 case reports A case report originating from the centre of evaluation and information on pharmacodependence-addictovigilance of Paris described ten patients (seven men and three women), aged 25 84 years, who developed dependence to mephenesin; most of these patients were abusing mephenesin at an overdose. Four of ten patients also developed dependence to alprazolam, zolpidem, promethazine, doxylamine, codeine or bromazepam. Three of...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46904-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p261 - 2 Jun 2018 O S Various toxicities: 10 case reports A case report originating from the centre of evaluation and information on pharmacodependence-addictovigilance of Paris described ten patients (seven men and three women), aged 25 84 years, who developed dependence to mephenesin; most of these patients were abusing mephenesin at an overdose. Four of ten patients also developed dependence to alprazolam, zolpidem, promethazine, doxylamine, codeine or bromazepam. Three of ten patients developed sleep disorder, anxiety, agitation, tremor or irritability following the withdrawal of mephenesin [routes, durations of treatments to reaction onsets and outcomes not stated, not all dosages and indication stated]. The patients had a history of depression, alcoholism, high BP, chronic obstructive pulmonary disease, fractured collarbone, capsulitis, sleep disorder, lumbar pain, childhood maltreatment, discal hernia, arthrosis, scoliosis, eating disorders, medication overuse headache, back pain or physical disability. Additionally, in six of the 10 patients, history was significant for alcoholism, overweight, gambling, illicit drugs use, alcohol abuse or cannabis use. The social history was significant for only tobacco (three patients), only alcohol (one patient) and both alcohol and tobacco (two patients). Seven of the ten patients were also receiving current medications. All the patients received

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

References

  • Mephenesin: Is There a Progression in Cases of Substance Use Related Disorders in France?.
    Chevallier, C

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