Multiple drugs

Multiple drugs Reactions 1704, p255 - 2 Jun 2018 labouring group was hypotension." "Adverse side effects of clonidine include. . .hypotension." "The only side effect we observed was hypotension that occurred in both patients at the 2 mg/mL dose and in 25% of those on the 1.2 mg/mL Hypotension and fetal decelerations: 4 case reports dose." "[P]atient 5 who developed fetal decelerations due to In an observational case study, four patients [3 women and significant hypotension." 1 neonate] were described, out of whom three women aged 24-27 years developed hypotension following treatment with ** Buprenorphine dosing frequency not clearly stated i.e per day 16mg buprenorphine, bupivacaine, fentanyl, epinephrine or or 16mg TID is not clearly mentioned clonidine and 1 neonate [age and sex not stated] developed † Buprenorphine dosing frequency not clearly stated i.e per day 16mg fetal decelerations secondary to maternal hypotension or 16mg TID is not clearly mentioned following treatment with buprenorphine, bupivacaine, Hoyt MR, et al. Use of epidural clonidine for the management of analgesia in the fentanyl, epinephrine and clonidine [not all routes and opioid addicted parturient on buprenorphine maintenance therapy: an observational outcomes stated]. study. International Journal of Obstetric Anesthesia 34: 67-72, May 2018. The 24-year-old woman received buprenorphine 8mg twice Available from: URL: http://doi.org/10.1016/j.ijoa.2018.01.001 - USA 803322773 daily for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing bupivacaine 0.125%, fentanyl 5 µg/mL and epinephrine 1.2 µg/mL. She received combined spinal epidural (CSE) with intrathecal fentanyl 10µg and bupivacaine 1.2mg. Later, she received bupivacaine 0.0625% with clonidine 2 µg/mL mixture. Initial analgesia had poor effect, and she was rescued with 100mg of epidural clonidine. After 10 minutes, her pain score was 0/10. She developed hypotension within 30 60 min after the initiation of epidural infusion. She underwent vaginal delivery at the gestational age of 36 weeks and 4 days. She received treatment with ibuprofen and ketorolac for her post delivery pain. The 27-year-old woman received buprenorphine 16mg per ** day for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing bupivacaine 0.125%, fentanyl 5 µg/mL and epinephrine 1.2 µg/mL. She received infusion solution of 1.2 µg/mL clonidine along with bupivacaine 0.1% at 10 mL/hour with a controlled bolus option of 5mL every 15 minutes. Immediately after the epidural therapy, her pain score was 0/10. She developed hypotension within 30 60 min after the initiation of epidural infusion. She underwent vaginal delivery at the gestational age of 41 weeks and 1 day. She received treatment with paracetamol [acetaminophen] and ibuprofen for her post-delivery pain. Despite treatment with phenylephrine and ephedrine, she developed fetal decelerations due to significant hypotension. She received fluid and continued vasopressor therapy, and her fetal decelerations resolved. After this episode, her epidural infusion rate was reduced from 10 to 6 mL/hour. The 26-year-old woman received buprenorphine 4mg twice daily for opioid addiction. She was managed with a combined spinal epidural technique. She received clonidine 2 µg/mL along with bupivacaine 0.0625% solution. After 1 day, her infusions were discontinued and the catheters were removed. She developed hypotension once within 60 min after the initiation of epidural infusion. She received treatment with fluid and phenylephrine boluses, and her hypotension recovered. She underwent caesarean delivery at the gestational age of 38 weeks and 6 day. The neonate [age and sex not stated] developed decelerations secondary to maternal hypotension following treatment with buprenorphine, bupivacaine, fentanyl, epinephrine and clonidine. The mother of neonate received buprenorphine 16mg per day for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing 0.125% bupivacaine, 5 µg/mL fentanyl and 1.2 µg/mL epinephrine. She received infusion solution of 1.2 µg/mL clonidine along with 0.1% bupivacaine at 10 mL/hour with a controlled bolus option of 5mL every 15 minutes. Immediately after the epidural therapy, her pain score was 0/10. She developed hypotension within 30 60 minutes after initiating the epidural infusion. The neonate was born via vaginal delivery. Later, the neonate developed decelerations due to significant maternal hypotension. The mother of neonate received fluid and continued vasopressors therapy, and the decelerations resolved. Author comment: "The only side effect seen in the 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Multiple drugs

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46898-z
Publisher site
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Abstract

Reactions 1704, p255 - 2 Jun 2018 labouring group was hypotension." "Adverse side effects of clonidine include. . .hypotension." "The only side effect we observed was hypotension that occurred in both patients at the 2 mg/mL dose and in 25% of those on the 1.2 mg/mL Hypotension and fetal decelerations: 4 case reports dose." "[P]atient 5 who developed fetal decelerations due to In an observational case study, four patients [3 women and significant hypotension." 1 neonate] were described, out of whom three women aged 24-27 years developed hypotension following treatment with ** Buprenorphine dosing frequency not clearly stated i.e per day 16mg buprenorphine, bupivacaine, fentanyl, epinephrine or or 16mg TID is not clearly mentioned clonidine and 1 neonate [age and sex not stated] developed † Buprenorphine dosing frequency not clearly stated i.e per day 16mg fetal decelerations secondary to maternal hypotension or 16mg TID is not clearly mentioned following treatment with buprenorphine, bupivacaine, Hoyt MR, et al. Use of epidural clonidine for the management of analgesia in the fentanyl, epinephrine and clonidine [not all routes and opioid addicted parturient on buprenorphine maintenance therapy: an observational outcomes stated]. study. International Journal of Obstetric Anesthesia 34: 67-72, May 2018. The 24-year-old woman received buprenorphine 8mg twice Available from: URL: http://doi.org/10.1016/j.ijoa.2018.01.001 - USA 803322773 daily for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing bupivacaine 0.125%, fentanyl 5 µg/mL and epinephrine 1.2 µg/mL. She received combined spinal epidural (CSE) with intrathecal fentanyl 10µg and bupivacaine 1.2mg. Later, she received bupivacaine 0.0625% with clonidine 2 µg/mL mixture. Initial analgesia had poor effect, and she was rescued with 100mg of epidural clonidine. After 10 minutes, her pain score was 0/10. She developed hypotension within 30 60 min after the initiation of epidural infusion. She underwent vaginal delivery at the gestational age of 36 weeks and 4 days. She received treatment with ibuprofen and ketorolac for her post delivery pain. The 27-year-old woman received buprenorphine 16mg per ** day for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing bupivacaine 0.125%, fentanyl 5 µg/mL and epinephrine 1.2 µg/mL. She received infusion solution of 1.2 µg/mL clonidine along with bupivacaine 0.1% at 10 mL/hour with a controlled bolus option of 5mL every 15 minutes. Immediately after the epidural therapy, her pain score was 0/10. She developed hypotension within 30 60 min after the initiation of epidural infusion. She underwent vaginal delivery at the gestational age of 41 weeks and 1 day. She received treatment with paracetamol [acetaminophen] and ibuprofen for her post-delivery pain. Despite treatment with phenylephrine and ephedrine, she developed fetal decelerations due to significant hypotension. She received fluid and continued vasopressor therapy, and her fetal decelerations resolved. After this episode, her epidural infusion rate was reduced from 10 to 6 mL/hour. The 26-year-old woman received buprenorphine 4mg twice daily for opioid addiction. She was managed with a combined spinal epidural technique. She received clonidine 2 µg/mL along with bupivacaine 0.0625% solution. After 1 day, her infusions were discontinued and the catheters were removed. She developed hypotension once within 60 min after the initiation of epidural infusion. She received treatment with fluid and phenylephrine boluses, and her hypotension recovered. She underwent caesarean delivery at the gestational age of 38 weeks and 6 day. The neonate [age and sex not stated] developed decelerations secondary to maternal hypotension following treatment with buprenorphine, bupivacaine, fentanyl, epinephrine and clonidine. The mother of neonate received buprenorphine 16mg per day for opioid addiction. Later, she received epidural labour analgesic therapy with 10mL of standard bolus solution containing 0.125% bupivacaine, 5 µg/mL fentanyl and 1.2 µg/mL epinephrine. She received infusion solution of 1.2 µg/mL clonidine along with 0.1% bupivacaine at 10 mL/hour with a controlled bolus option of 5mL every 15 minutes. Immediately after the epidural therapy, her pain score was 0/10. She developed hypotension within 30 60 minutes after initiating the epidural infusion. The neonate was born via vaginal delivery. Later, the neonate developed decelerations due to significant maternal hypotension. The mother of neonate received fluid and continued vasopressors therapy, and the decelerations resolved. Author comment: "The only side effect seen in the 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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