Reactions 1704, p259 - 2 Jun 2018 Stem cell mobilization failure : case report A 14-year-old girl experienced stem cell mobilization failure following treatment with vincristine, ifosfamide, doxorubicin, etoposide, cyclophosphamide, temozolomide, irinotecan and bevacizumab [time to reaction onset not stated]. The girl, who was diagnosed with extraosseus stage I Ewing’s sarcoma in April 2009, started receiving treatment with IV vincristine 1.5 mg/m on day 1, IV ifosfamide 2 2 3,000 mg/m on days 1–3, IV doxorubicin 20 mg/m on days 1–3, IV etoposide 150 mg/m on days 1–3 (every three weeks x 6 cycles). She completed 6 cycles prior to surgical resection. In October 2009, she received 8 cycles of consolidation with vincristine IV 1.5 mg/m2 on day 1, IV actinomycin (unspecified) 0.75 mg/m on days 1–2 and IV cyclophosphamide 1,500 mg/m on day 1 (every three weeks x 8 cycles). In April 2010, she developed early relapse and a second chemotherapy line was given with 5 cycles of oral temozolomide 100 mg/m on days 1–21, IV irinotecan 20 mg/m on days 1–5 and 8–13 and IV bevacizumab 350 mg/m on day 1 (every 21 days x 5 cycles). In July 2010, a second surgical resection plus radiotherapy localized in left humeral bone was performed. Due to this chemotherapeutic treatment, she developed stem cell mobilization failure. In response to this, she received first mobilisation regimen included granulocyte colony-stimulating factor (G-CSF). A second mobilisation with chemotherapy followed by G-CSF. However, both the therapies led to insufficient count of CD34+ cell (3/µL) in peripheral blood. Later, she received single compassionate dose of plerixafor, with the CD34+ cell count being 24.5/µL. Total of 1.38 x 10e6 CD34+ cells/kg were collected in a single apheresis processing 5 blood volumes. Autologous stem cell transplant was performed. Author comment: "The number of chemotherapy courses and pretreatment with alkylating agents and platinum compounds. . . are associated with [stem cell mobilization] failure." Vives S, et al. Plerixafor plus G-CSF in combination with chemotherapy for stem cell mobilization in a pediatric patient with Ewing’s sarcoma. Journal of Clinical Apheresis 27: 260-262, No. 5, Nov 2018. Available from: URL: https:// doi.org/10.1002/jca.21234 - Spain 803323920 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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