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Multiple drugs

Multiple drugs Reactions 1704, p268 - 2 Jun 2018 Various toxicities: case report A girl [age at reactions onsets not clearly stated] developed nausea, vomiting, abscess, anorexia and exhibited low blood counts in the form of thrombocytopenia and neutropenia during treatment with multiple drugs for refractory choroid plexus carcinomas [time to reactions onsets not stated; not all routes stated]. The girl, who presented in January 2011 at the age of 4 months with increased emesis and a bulging fontanelle, was diagnosed with choroid plexus carcinomas (CPC) in the right ventricle with metastatic tumour cells present in the CSF and leptomeningeal carcinomatosis. After a complete tumour resection, she received 12 cycles (cyclophosphamide, carboplatin, etoposide) according to published CPC therapy and was in remission. In August 2012 (at the age of 23 months), the tumour recurred. From September November 2012, she received 3 cycles of irinotecan 125 mg/m , bevacizumab 10 mg/kg and temozolomide [temodar] 140 mg/m × 5 days; however, she developed grade >2 events such as thrombocytopenia and neutropenia. From December January 2013, she received 2 2 2 cycles of methotrexate 8 gm/m and vincristine 1.5 mg/m , but she developed grade >2 events consisted of vomiting and nausea. From March http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Multiple drugs

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Multiple drugs

Abstract

Reactions 1704, p268 - 2 Jun 2018 Various toxicities: case report A girl [age at reactions onsets not clearly stated] developed nausea, vomiting, abscess, anorexia and exhibited low blood counts in the form of thrombocytopenia and neutropenia during treatment with multiple drugs for refractory choroid plexus carcinomas [time to reactions onsets not stated; not all routes stated]. The girl, who presented in January 2011 at the age of 4 months with increased emesis and a bulging fontanelle, was...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46911-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p268 - 2 Jun 2018 Various toxicities: case report A girl [age at reactions onsets not clearly stated] developed nausea, vomiting, abscess, anorexia and exhibited low blood counts in the form of thrombocytopenia and neutropenia during treatment with multiple drugs for refractory choroid plexus carcinomas [time to reactions onsets not stated; not all routes stated]. The girl, who presented in January 2011 at the age of 4 months with increased emesis and a bulging fontanelle, was diagnosed with choroid plexus carcinomas (CPC) in the right ventricle with metastatic tumour cells present in the CSF and leptomeningeal carcinomatosis. After a complete tumour resection, she received 12 cycles (cyclophosphamide, carboplatin, etoposide) according to published CPC therapy and was in remission. In August 2012 (at the age of 23 months), the tumour recurred. From September November 2012, she received 3 cycles of irinotecan 125 mg/m , bevacizumab 10 mg/kg and temozolomide [temodar] 140 mg/m × 5 days; however, she developed grade >2 events such as thrombocytopenia and neutropenia. From December January 2013, she received 2 2 2 cycles of methotrexate 8 gm/m and vincristine 1.5 mg/m , but she developed grade >2 events consisted of vomiting and nausea. From March

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

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