J Clin Immunol (2017) 37:519–523 DOI 10.1007/s10875-017-0419-1 LETTER TO EDITOR Multiple Brain Abscesses Caused by Trichosporon inkin in a Patient with X-Linked Chronic Granulomatous Disease (CGD) Successfully Treated with Antifungal Therapy 1,2 1 3 3 Joud Hajjar & Alejandro Restrepo & Heta Javeri & Nathan P. Wiederhold & 3 3,4 Alexander M. Papanastassiou & Thomas F. Patterson Received: 17 February 2017 /Accepted: 3 July 2017 /Published online: 11 July 2017 Springer Science+Business Media, LLC 2017 Abbreviations history and abnormal dihydrorhodamine (DHR) flow cytom- CGD chronic granulomatous disease etry test. Genetic testing showed deletion of the entire CYBB T. Inkin trichosporon inkin gene confirming the diagnosis of X-linked CGD. His course HSCT hematopoietic stem cell transplant was complicated by Aspergillus pneumonia at less than 1 year CT computed tomography of age that resulted in the initiation of prophylactic MRI magnetic resonance imaging itraconazole, recurrent otitis media resulting in bilateral mas- BHI brain heart infusion toidectomy, two anal fistulas requiring surgical removal, re- MIC minimum inhibitory concentrations current coagulase negative staphylococcus facial abscesses IV intravenous requiring multiple drainages, microaerophilic streptococci liv- AIDS acquired immunodeficiency syndrome er abscess resulting in lobectomy, intestinal amoebiasis; staph- AML acute myeloid leukemia ylococcal sinusitis, and various
Journal of Clinical Immunology – Springer Journals
Published: Jul 11, 2017
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