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Multifunctional Lipoamino Acid Derivatives with Potential Biological Activity

Multifunctional Lipoamino Acid Derivatives with Potential Biological Activity This work aims to develop a number of multifunctional derivatives of lipoamino acids, which potentially have different biological activities. To achieve this aim, the hydrophilic-lipophilic balance for a number of cationic amphiphile structures based on L-glutamic acid and short diamines is theoretically calculated. The developed schemes and performed synthesis allowed us to produce preparative sample quantities for further physicochemical and biological tests. The performed calculations, measurements, and experiments on the liposomal dispersions of the synthesized compounds demonstrate the possibility of designing the same type of structures of an amphiphilic nature based on aliphatic amino acid derivatives and diamines, which can be used both in antibacterial therapy and as the delivery vehicles for genetic material. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Chemistry Bulletin Springer Journals

Multifunctional Lipoamino Acid Derivatives with Potential Biological Activity

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References (10)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Allerton Press, Inc.
Subject
Chemistry; Chemistry/Food Science, general
ISSN
0027-1314
eISSN
1935-0260
DOI
10.3103/S0027131418020098
Publisher site
See Article on Publisher Site

Abstract

This work aims to develop a number of multifunctional derivatives of lipoamino acids, which potentially have different biological activities. To achieve this aim, the hydrophilic-lipophilic balance for a number of cationic amphiphile structures based on L-glutamic acid and short diamines is theoretically calculated. The developed schemes and performed synthesis allowed us to produce preparative sample quantities for further physicochemical and biological tests. The performed calculations, measurements, and experiments on the liposomal dispersions of the synthesized compounds demonstrate the possibility of designing the same type of structures of an amphiphilic nature based on aliphatic amino acid derivatives and diamines, which can be used both in antibacterial therapy and as the delivery vehicles for genetic material.

Journal

Moscow University Chemistry BulletinSpringer Journals

Published: May 30, 2018

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