Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology

Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and... Background Numerous articles related to S100 proteins have been recently published. This review aims to introduce this large protein family and its importance in the diagnostics of many pathological conditions in children and adults. Data sources Based on original publications found in database systems, we summarize the current knowledge about the S100 protein group and highlight the most important proteins with focus on pediatric use. 2+ 2+ Results The S100 family is composed of Ca and Zn  binding proteins, which are present only in vertebrates. Some of these proteins can be used as diagnostic markers in cardiology (S100A1, S100A12), oncology (S100A2, S100A5, S100A6, S100A14, S100A16, S100P, S100B), neurology (S100B), rheumatology (S100A8/A9, S100A4, S100A6, and S100A12), nephrology and infections (S100A8, S100A9, S100A8/A9, S100A12). The most useful S100 proteins in pediatrics are S100A8, S100A9, heterodimers S100A8/A9, S100B and S100A12. Conclusions The S100 family members are promising biomarkers and provide numerous possibilities for implementation into clinical practice to optimize the differential diagnostic process. Keywords S100 · Diagnostics · Marker · Pediatrics Introduction extracellular function only while others have both of the men- tioned roles [9]. After they transit from intracellular to extracel- S100 proteins, found only in vertebrates [1], are low molecu- lular space, they begin to act as alarmins, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Pediatrics Springer Journals

Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology

7 pages
Read Article

Loading next page...
 
/lp/springer_journal/multifarious-diagnostic-possibilities-of-the-s100-protein-family-t0lVIuOTSl
Publisher
Springer Journals
Copyright
Copyright © 2018 by Children's Hospital, Zhejiang University School of Medicine
Subject
Medicine & Public Health; Pediatrics; Pediatric Surgery; Maternal and Child Health; Intensive / Critical Care Medicine; Surgery; Imaging / Radiology
ISSN
1708-8569
eISSN
1867-0687
D.O.I.
10.1007/s12519-018-0163-5
Publisher site
See Article on Publisher Site

Abstract

Background Numerous articles related to S100 proteins have been recently published. This review aims to introduce this large protein family and its importance in the diagnostics of many pathological conditions in children and adults. Data sources Based on original publications found in database systems, we summarize the current knowledge about the S100 protein group and highlight the most important proteins with focus on pediatric use. 2+ 2+ Results The S100 family is composed of Ca and Zn  binding proteins, which are present only in vertebrates. Some of these proteins can be used as diagnostic markers in cardiology (S100A1, S100A12), oncology (S100A2, S100A5, S100A6, S100A14, S100A16, S100P, S100B), neurology (S100B), rheumatology (S100A8/A9, S100A4, S100A6, and S100A12), nephrology and infections (S100A8, S100A9, S100A8/A9, S100A12). The most useful S100 proteins in pediatrics are S100A8, S100A9, heterodimers S100A8/A9, S100B and S100A12. Conclusions The S100 family members are promising biomarkers and provide numerous possibilities for implementation into clinical practice to optimize the differential diagnostic process. Keywords S100 · Diagnostics · Marker · Pediatrics Introduction extracellular function only while others have both of the men- tioned roles [9]. After they transit from intracellular to extracel- S100 proteins, found only in vertebrates [1], are low molecu- lular space, they begin to act as alarmins,

Journal

World Journal of Pediatrics – Springer Journals

Published: Jun 1, 2018

References

  • The S100 family of EF-hand calcium-binding proteins: functions and pathology
    Schäfer, BW; Heizmann, CW
  • Intracellular and extracellular roles of S100 proteins
    Donato, R
  • Ions binding to S100 proteins. I. Calcium- and zinc-binding properties of bovine brain S100αα, S100a (αβ), and S100b (ββ) protein: Zn2+ regulates Ca2+ binding on S100b protein
    Baudier, J; Glasser, N; Gerard, D
  • Binding of transition metals to S100 proteins
    Gilston, BA; Skaar, EP; Chazin, WJ
  • A soluble protein characteristic of the nervous system
    Moore, B
  • S100 proteins in cancer
    Bresnick, AR; Weber, DJ; Zimmer, DB
  • S100 protein in breast tumor
    Li, F; Men, X; Zhang, W
  • S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
    Donato, R
  • Functions of S100 proteins
    Donato, R; Cannon, BR; Sorci, G; Riuzzi, F; Hsu, K; Weber, DJ
  • HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
    Bertheloot, D; Latz, E
  • Alarmins in chronic noncommunicable diseases: atherosclerosis, diabetes and cancer
    Boteanu, RM; Suica, VI; Uyy, E; Ivan, L; Dima, SO; Popescu, I
  • The metastasis-promoting S100A4 protein confers neuroprotection in brain injury
    Dmytriyeva, O; Pankratova, O; Owczarek, S; Sonn, K; Soroka, V; Ridley, CM
  • S100B protein is released by in vitro trauma and reduces delayed neuronal injury
    Willoughby, KA; Kleindienst, A; Müller, C; Chen, T; Muir, JK; Ellis, EF
  • S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons
    Ellis, EF; Willoughby, KA; Sparks, SA; Chen, T
  • The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
    Sorci, G; Giovannini, G; Riuzzi, F; Bonifazi, P; Zelante, T; Zagarella, S
  • S100A8 modulates mast cell function and suppresses eosinophil migration in acute asthma
    Zhao, J; Endoh, I; Hsu, K; Tedla, N; Endoh, Y; Geczy, CL
  • Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds
    Caldwell, RL; Opalenik, SR; Davidson, JM; Caprioli, RM; Nanney, LB
  • Ala42S100A8 ameliorates psychological-stress impaired cutaneous wound healing
    Sroussi, HY; Williams, RL; Zhang, QL; Villines, D; Marucha, PT
  • Physiological aspects of Toll-like receptor 4 activation in sepsis-induced acute kidney injury
    Anderberg, SB; Luther, T; Frithiof, R
  • Distinct responses to monocytes to Toll-like receptor ligands and inflammatory cytokines
    Farina, C; Theil, D; Semlinger, B; Hohlfeld, R; Meinl, E
  • Toll-like receptors stimulate human neutrophil function
    Hayashi, F; Means, TK; Luster, AD
  • Toll-like receptors and innate immunity
    Medzhitov, R
  • Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis
    Ramasamy, R; Yan, SF; Herold, K; Clynes, R; Schmidt, AM
  • RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
    Chavakis, T; Bierhaus, A; Nawroth, PP
  • RAGE in tissue homeostasis, repair and regeneration
    Sorci, G; Riuzzi, F; Giambanco, I; Donato, R
  • HMGB1–RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription
    Riuzzi, F; Sorci, G; Sagheddu, R; Donato, R
  • Translocation of S100A1 calcium binding protein during heart surgery
    Brett, W; Mandinova, A; Remppis, A; Sauder, U; Rüter, F; Heizmann, CW
  • S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes
    Reppel, M; Sasse, P; Piekorz, R; Tang, M; Roell, W; Duan, Y
  • Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction
    Most, P; Seifert, H; Gao, E; Funakoshi, H; Völkers, M; Heierhorst, J
  • Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
    Most, P; Pleger, ST; Völkers, M; Heidt, B; Boerries, M; Weichenhan, D
  • S100A8 and S100A9 in cardiovascular biology and disease
    Averill, MM; Kerkhoff, C; Bornfeldt, KE
  • S100A6 protein: functional roles
    Donato, R; Sorci, G; Giambanco, I
  • Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern
    Petzold, A; Keir, G; Lim, D; Smith, M; Thompson, EJ
  • On the release and half-life of S100B protein in the peripheral blood of melanoma patients
    Ghanem, G; Loir, B; Morandini, R; Sales, F; Lienard, D; Eggermont, A
  • Kinetic modelling of serum S100b after traumatic brain injury
    Ercole, A; Thelin, EP; Holst, A; Bellander, BM; Nelson, DW
  • Serum levels of protein S100B predict intracranial lesions in mild head injury
    Cervellin, G; Benatti, M; Carbucicchio, A; Mattei, L; Cerasti, D; Aloe, R; Lippi, G
  • Calprotectin as a biomarker for rheumatoid arthritis: a systematic review
    Abildtrup, M; Kingsley, GH; Scott, DL
  • Elevated expressions of myeloid-related proteins-8 and -14 are danger biomarkers for lupus nephritis
    Tantivitayakul, P; Benjachat, T; Somparn, P; Leelahavanichkul, A; Kittikovit, V; Hirankarn, N
  • Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues
    Winningham-Major, F; Staecker, JL; Barger, SW; Coats, S; Eldik, LJ
  • S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages
    Wang, H; Zhang, L; Zhang, IY; Chen, X; Fonseca, A; Wu, S
  • The evolution of S100B inhibitors for the treatment of malignant melanoma
    Hartman, KG; McKnight, LE; Liriano, MA; Weber, DJ
  • S100β as a serum marker in endocrine resistant breast cancer
    Charmsaz, S; Hughes, É; Bane, FT; Tibbitts, P; McIlroy, M; Byrne, C
  • Use of a combination of approaches to identify and validate relevant tumor-associated antigens and their corresponding autoantibodies in ovarian cancer patients
    Gagnon, A; Kim, JH; Schorge, JO; Ye, B; Liu, B; Hasselblatt, K
  • Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas
    Zhang, H; Zhao, Q; Chen, Y; Wang, Y; Gao, S; Mao, Y
  • Clinicopathological and prognostic significance of S100A4 overexpression in colorectal cancer: a meta-analysis
    Liu, Y; Tang, W; Wang, J; Xie, L; Li, T; He, Y
  • Proteins S100A8 and S100A9 are potential biomarkers for renal cell carcinoma in the early stages: results from a proteomic study integrated with bioinformatics analysis
    Zhang, L; Jiang, H; Xu, G; Wen, H; Gu, B; Liu, J
  • Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes
    Kraakman, MJ; Lee, MK; Al-Sharea, A; Dragoljevic, D; Barret, TJ; Montenont, E
  • Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity
    Lee, RH; Bergmeier, W
  • Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitustype 2 patients
    Krisp, C; Jacobsen, F; McKay, MJ; Molloy, MP; Steinstraesser, L; Wolters, DA
  • Role of calprotectin in infection and inflammation
    Dhas, B; Bha, VT; Gane, B
  • Release and quantitation of a leukocyte derived protein (L1)
    Fagerhol, MK; Dale, I; Andersson, T
  • A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues
    Zwadlo, G; Schlegel, R; Sorg, C
  • A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene
    Dorin, JR; Novak, M; Hill, RE; Brock, DJ; Secher, DS; Heyningen, V
  • Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
    Odink, K; Cerletti, N; Brüggen, J; Clerc, RG; Tarcsay, L; Zwado, G
  • The leucocyte L1 protein: identity with the cystic fibrosis antigen and the calcium-binding MRP-8 and MRP-14 macrophage components
    Andersson, KB; Sletten, K; Berntzen, HB; Dale, I; Brandtzaeg, P; Jellum, E
  • Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues
    Wilkinson, MM; Busuttil, A; Hayward, C; Brock, DJ; Dorin, JR; Heyningen, V
  • Monoclonal antibody 5.5 reacts with p8,14, a myeloid molecule associated with some vascular endothelium
    Hogg, N; Allen, C; Edgeworth, J
  • Amino acid sequences of 60B8 antigens induced in HL-60 cells by 1,25-dihydroxyvitamin D3. The antigens are identical with macrophage-related protein-14 and -8
    Tobe, T; Murakami, K; Tomita, M; Nozawa, R
  • Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
    Steinbakk, M; Naess-Andersen, CF; Lingaas, E; Dale, I; Brandtzaeg, P; Fagerhol, MK
  • Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    Schafer, BW; Wicki, R; Engelkamp, D; Mattei, MG; Heizmann, CW
  • Calprotectin—a pleiotropic molecule in acute and chronic inflammation
    Stříž, I; Trebichavský, I
  • MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes
    Hessian, PA; Edgeworth, J; Hogg, N
  • MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
    Vogl, T; Ludwig, S; Goebeler, M; Strey, A; Thorey, IS; Reichelt, R
  • Serum calprotectin: review of its usefulness and validity in pediatric rheumatic diseases
    Mariani, A; Marsili, M; Nozzi, M; Faricelli, R; Chiarelli, F; Breda, L
  • Fecal calprotectin as an activity marker of inflammatory bowel disease in children
    Krzesiek, E
  • Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis
    Rheenen, PF; Vijver, E; Fidler, V
  • Schreuder aB, Cnossen WR, Muller Kobold aC, van Rheenen PF. Safely ruling out inflammatory bowel disease in children and teenagers without referral for endoscopy
    Vijver, E
  • Faecal calprotectin in treated and untreated children with coeliac disease and juvenile idiopathic arthritis
    Biskou, O; Gardner-Medwin, J; Mackinder, M; Bertz, M; Clark, C; Svolos, V
  • Leptin, ghrelin and calprotectin: inflammatory markers in childhood asthma?
    Cobanoglu, N; Galip, N; Dalkan, C; Bahceciler, NN
  • Calprotectin as a marker of inflammation in cystic fibrosis
    Golden, BE; Clohessy, PA; Russell, G; Fagerhol, MK
  • Sputum and serum calprotectin are useful biomarkers during CF exacerbation
    Gray, RD; Imrie, M; Boyd, AC; Porteous, D; Innes, JA; Greening, AP
  • Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation
    Horsley, AR; Davies, JC; Gray, RD; Macleod, KA; Donovan, J; Aziz, ZA
  • MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis
    Anink, J; Suijlekom-Smit, LW; Otten, MH; Prince, FH; Rossum, MA; Dolman, KM
  • Gene expression profiling of the effect of high-dose intravenous Ig in patients with Kawasaki disease
    Abe, J; Jibiki, T; Noma, S; Nakajima, T; Saito, H; Terai, M
  • Clinical update: Henoch Schonlein Purpura
    Saulsbury, FT
  • Henoch Schonlein Purpura in children: clinical analysis of 120 cases
    Chen, O; Zhu, XB; Ren, P; Wang, YB; Sun, RP; Wei, DE
  • Urine S100 proteins as potential biomarkers of lupus nephritis activity
    Turnier, JL; Fall, N; Thornton, S; Witte, D; Bennett, MR; Appenzeller, S
  • Calprotectin levels in necrotizing enterocolitis: a systematic review of the literature
    Pergialiotis, V; Konstantopoulos, P; Karampetsou, N; Koutaki, D; Gkioka, E; Perrea, DN
  • Fecal calprotectin: cutoff values for identifying intestinal distress in preterm infants
    Campeotto, F; Baldassarre, M; Butel, MJ; Viallon, V; Nganzali, F; Soulaines, P
  • Dynamic change of fecal calprotectin in very low birth weight infants during the first month of life
    Yang, Q; Smith, PB; Goldberg, RN; Cotton, CM
  • Fecal calprotectin in very low birth weight infants
    Josefsson, S; Bunn, SK; Domellof, M
  • Fecal calprotectin concentrations in premature infants have a lower limit and show postnatal and gestational age dependence
    Zoppelli, L; Güttel, C; Bittrich, HJ; Andrée, C; Wirth, S; Jenke, A
  • Human S100A12: a novel key player in inflammation?
    Pietzsch, J; Hoppmann, S
  • Identification and characterization of a novel human neutrophil protein related to the S100 family
    Guignard, F; Mauel, J; Markert, M
  • S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity
    Yang, Z; Yan, WX; Cai, H; Tedla, N; Armishaw, C; Girolamo, N
  • Serum levels of soluble receptor for advanced glycation endproducts (sRAGE) are higher in ulcerative colitis and correlate with disease activity
    Yilmaz, Y; Yonal, O; Eren, F; Atug, O; Hamzaoglu, HO
  • Fecal S100A12: identifying intestinal distress in very-low-birth-weight infants
    Däbritz, J; Foell, D; Wirth, S; Jenke, A
  • Fecal phagocyte-specific S100A12 for diagnosing necrotizing enterocolitis
    Däbritz, J; Jenke, A; Wirth, S; Foell, D
  • Serum calprotectin: an antimicrobial peptide as a new marker for the diagnosis of sepsis in very low birth weight newborns
    Terrin, G; Passariello, A; Manguso, F; Salvia, G; Rapacciuolo, L; Messina, F
  • Serum calprotectin as a diagnostic marker of late onset sepsis in full-term neonates
    Abdel-Maaboud, M; El-Mazary, AA; Osman, AM
  • Serum calprotectin: a potential biomarker for neonatal sepsis
    Decembrino, L; Amici, M; Pozzi, M; Silvestri, A; Stronati, M
  • Neonatology: pathophysiology and management of the newborn
    Avery, GB; Fletcher, MA; MacDonald, MG
  • S100B protein is increased in asphyxiated term infants developing intraventricular hemorrhage
    Gazzolo, D; Iorio, R; Marioni, E; Masetti, P; Serra, G; Giovannini, L
  • Increased urinary S100B protein as an early indicator of intraventricular hemorrhage in preterm infants: correlation with the grade of hemorrhage
    Gazzolo, D; Bruschettini, M; Lituania, M; Serra, G; Bonacci, W; Michetti, F
  • Urinary S100B protein measurements: a tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infants
    Gazzolo, D; Marinoni, E; Iorio, R; Bruschettini, M; Kornacka, M; Lituania, M

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial