Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations

Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations Background Gastric cancer (GC) is one of the high-incidence and high-mortality cancers all over the world. Though genome- wide association studies (GWASs) have found some genetic loci related to GC, they could only explain a small fraction of the potential pathogenesis for GC. Methods We used multi-marker analysis of genomic annotation (MAGMA) to analyze pathways from four public pathway databases based on Chinese GWAS data including 2631 GC cases and 4373 controls. The differential expressions of selected genes in certain pathways were assessed on the basis of The Cancer Genome Atlas database. Immunohistochemistry was also conducted on 55 GC and paired normal tissues of Chinese patients to localize the expression of genes and further validate the differential expression. Results We identified three pathways including chemokine signaling pathway, potassium ion import pathway, and inter - leukin-7 (IL7) pathway, all of which were associated with GC risk. NMI in IL7 pathway and RAC1 in chemokine signaling pathway might be two new candidate genes involved in GC pathogenesis. Additionally, NMI and RAC1 were overexpressed in GC tissues than normal tissues. Conclusion Immune and inflammatory associated processes and potassium transporting might participate in the development of GC. Besides, NMI and RAC1 might represent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gastric Cancer Springer Journals

Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations

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Publisher
Springer Japan
Copyright
Copyright © 2018 by The International Gastric Cancer Association and The Japanese Gastric Cancer Association
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Abdominal Surgery; Gastroenterology; Cancer Research
ISSN
1436-3291
eISSN
1436-3305
D.O.I.
10.1007/s10120-018-0841-y
Publisher site
See Article on Publisher Site

Abstract

Background Gastric cancer (GC) is one of the high-incidence and high-mortality cancers all over the world. Though genome- wide association studies (GWASs) have found some genetic loci related to GC, they could only explain a small fraction of the potential pathogenesis for GC. Methods We used multi-marker analysis of genomic annotation (MAGMA) to analyze pathways from four public pathway databases based on Chinese GWAS data including 2631 GC cases and 4373 controls. The differential expressions of selected genes in certain pathways were assessed on the basis of The Cancer Genome Atlas database. Immunohistochemistry was also conducted on 55 GC and paired normal tissues of Chinese patients to localize the expression of genes and further validate the differential expression. Results We identified three pathways including chemokine signaling pathway, potassium ion import pathway, and inter - leukin-7 (IL7) pathway, all of which were associated with GC risk. NMI in IL7 pathway and RAC1 in chemokine signaling pathway might be two new candidate genes involved in GC pathogenesis. Additionally, NMI and RAC1 were overexpressed in GC tissues than normal tissues. Conclusion Immune and inflammatory associated processes and potassium transporting might participate in the development of GC. Besides, NMI and RAC1 might represent

Journal

Gastric CancerSpringer Journals

Published: Jun 1, 2018

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