Introduction Dermatomyositis (DM) is an idiopathic inflammatory myopathy involving severe debilitation in need of diagnos- tics. We evaluated the proximal lower extremity musculature with diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM) and dynamic DTI in DM patients and controls and compared with standard clinical workup. Methods In this IRB-approved, HIPAA-compliant study with written informed consent, anatomical, Dixon fat/water and diffu- sion imaging were collected in bilateral thigh MRI of 22 controls and 27 DM patients in a 3Tscanner. Compartments were scored on T1/T2 scales. Single voxel dynamic DTI metrics in quadriceps before and after 3-min leg exercise were measured. Spearman rank correlation and mixed model analysis of variance/covariance (ANOVA/ANCOVA) were used to correlate with T1 and T2 scores and to compare patients with controls. Results DM patients showed significantly lower pseudo-diffusion and volume in quadriceps than controls. All subjects showed significant correlation between T1 score and signal-weighted fat fraction; tissue diffusion and pseudo-diffusion varied signifi- cantly with T1 and T2 score in patients. Radial and mean diffusion exercise response in patients was significantly higher than controls. Conclusion Static and dynamic diffusion imaging metrics show correlation with conventional imaging scores, reveal spatial heterogeneity, and provide means to differentiate dermatomyositis
European Radiology – Springer Journals
Published: Jun 4, 2018
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