mPGES-1 and ALOX5/-15 in tumor-associated macrophages

mPGES-1 and ALOX5/-15 in tumor-associated macrophages The tumor immune landscape gained considerable interest based on the knowledge that genetic aberrations in cancer cells alone are insufficient for tumor development. Macrophages are basically supporting all hallmarks of cancer and owing to their tremendous plasticity they may exert a whole spectrum of anti-tumor and pro-tumor activities. As part of the innate immune response, macrophages are armed to attack tumor cells, alone or in concert with distinct T cell subsets. However, in the tumor microenvironment, they sense nutrient and oxygen gradients, receive multiple signals, and respond to this incoming information with a phenotype shift. Often, their functional output repertoire is shifted to become tumor-supportive. Incoming and outgoing signals are chemically heterogeneous but also comprise lipid mediators. Here, we review the current understanding whereby arachidonate metabolites derived from the cyclooxygenase and lipoxygenase pathways shape the macrophage phenotype in a tumor setting. We discuss these findings in the context of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase- 1 (mPGES-1) expression and concomitant prostaglandin E (PGE ) formation. We elaborate the multiple actions of this lipid in 2 2 affecting macrophage biology, which are sensors for and generators of this lipid. Moreover, we summarize properties of 5- lipoxygenases (ALOX5) and 15-lipoxygenases http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer and Metastasis Reviews Springer Journals

mPGES-1 and ALOX5/-15 in tumor-associated macrophages

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Cancer Research; Oncology; Biomedicine, general
ISSN
0167-7659
eISSN
1573-7233
D.O.I.
10.1007/s10555-018-9731-3
Publisher site
See Article on Publisher Site

Abstract

The tumor immune landscape gained considerable interest based on the knowledge that genetic aberrations in cancer cells alone are insufficient for tumor development. Macrophages are basically supporting all hallmarks of cancer and owing to their tremendous plasticity they may exert a whole spectrum of anti-tumor and pro-tumor activities. As part of the innate immune response, macrophages are armed to attack tumor cells, alone or in concert with distinct T cell subsets. However, in the tumor microenvironment, they sense nutrient and oxygen gradients, receive multiple signals, and respond to this incoming information with a phenotype shift. Often, their functional output repertoire is shifted to become tumor-supportive. Incoming and outgoing signals are chemically heterogeneous but also comprise lipid mediators. Here, we review the current understanding whereby arachidonate metabolites derived from the cyclooxygenase and lipoxygenase pathways shape the macrophage phenotype in a tumor setting. We discuss these findings in the context of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase- 1 (mPGES-1) expression and concomitant prostaglandin E (PGE ) formation. We elaborate the multiple actions of this lipid in 2 2 affecting macrophage biology, which are sensors for and generators of this lipid. Moreover, we summarize properties of 5- lipoxygenases (ALOX5) and 15-lipoxygenases

Journal

Cancer and Metastasis ReviewsSpringer Journals

Published: May 28, 2018

References

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