Short Communications Incorporating Mouse Genome Mammalian Genome 10, 923–925 (1999). © Springer-Verlag New York Inc. 1999 Mouse Wnt8B is expressed in the developing forebrain and maps to Chromosome 19 1 2, 2, 1, Melville Richardson, Diane Redmond, * Christine J. Watson, ** John O. Mason *** Centre for Genome Research, Roger Land Building, University of Edinburgh, Edinburgh EH9 3JQ, UK Roslin Institute, Roslin, Midlothian, EH25 9PS, UK Received: 1 March 1999 / Accepted: 17 May 1999 The Wnt gene family encodes a set of intercellular signaling mol- as a probe to screen a d8.5 mouse embryo cDNA library (gift from ecules implicated in the regulation of a wide range of basic devel- W.C. Skarnes); one clone was isolated and found to contain an opmental processes. Both spontaneous mutations and gene- insert of 693 bp. Sequence analysis showed this to be derived from knockout studies have demonstrated the importance of a number of the 38 end of the transcript, containing the last 246 nucleotides of these in normal mouse development. Wnts are involved in the coding sequence and 447 bp of 38 untranslated sequence. We then regulation of development of the midbrain, limbs, kidneys, and a isolated a genomic clone
Mammalian Genome – Springer Journals
Published: Sep 1, 1999
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