Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5

Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5 Short Communications Incorporating Mouse Genome Mammalian Genome 12, 73–76 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350010231 Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5 Chengtao Her, Xiling Wu, Susan M. Bailey, Norman A. Doggett Bioscience Division, Mail Stop: M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA Received: 5 April 2000 / Accepted: 31 August 2000 Eukaryotic MutS homologs define a group of evolutionary con- interacts with hMSH4, suggesting the existence of an hMSH4-like served proteins that are involved in multiple biological functions protein in the mouse (Her et al. 1999). including postreplicative DNA mismatch repair, genetic recombi- To facilitate the understanding of biological functions of nation, and cellular responses to DNA damaging agents (Buerm- MSH4 and MSH5 in mammals, we have now identified and char- eyer et al. 1999). During postreplicative mismatch repair, heterodi- acterized the mouse MutS homolog 4 (Msh4) by a homology- meric MutS homologous proteins initiate repair processes by rec- based cloning approach from a mouse testis Marathon-Ready ognizing and binding to the mispaired nucleotides (Kolodner cDNAs preparation (Clontech Laboratories, Palo Alto, Calif). The 1996). Germline mutations in at least five human mismatch repair http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5

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Publisher
Springer-Verlag
Copyright
Copyright © 2001 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010231
Publisher site
See Article on Publisher Site

Abstract

Short Communications Incorporating Mouse Genome Mammalian Genome 12, 73–76 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350010231 Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5 Chengtao Her, Xiling Wu, Susan M. Bailey, Norman A. Doggett Bioscience Division, Mail Stop: M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA Received: 5 April 2000 / Accepted: 31 August 2000 Eukaryotic MutS homologs define a group of evolutionary con- interacts with hMSH4, suggesting the existence of an hMSH4-like served proteins that are involved in multiple biological functions protein in the mouse (Her et al. 1999). including postreplicative DNA mismatch repair, genetic recombi- To facilitate the understanding of biological functions of nation, and cellular responses to DNA damaging agents (Buerm- MSH4 and MSH5 in mammals, we have now identified and char- eyer et al. 1999). During postreplicative mismatch repair, heterodi- acterized the mouse MutS homolog 4 (Msh4) by a homology- meric MutS homologous proteins initiate repair processes by rec- based cloning approach from a mouse testis Marathon-Ready ognizing and binding to the mispaired nucleotides (Kolodner cDNAs preparation (Clontech Laboratories, Palo Alto, Calif). The 1996). Germline mutations in at least five human mismatch repair

Journal

Mammalian GenomeSpringer Journals

Published: Jan 1, 2001

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