Short Communications Incorporating Mouse Genome Mammalian Genome 12, 73–76 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350010231 Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5 Chengtao Her, Xiling Wu, Susan M. Bailey, Norman A. Doggett Bioscience Division, Mail Stop: M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA Received: 5 April 2000 / Accepted: 31 August 2000 Eukaryotic MutS homologs define a group of evolutionary con- interacts with hMSH4, suggesting the existence of an hMSH4-like served proteins that are involved in multiple biological functions protein in the mouse (Her et al. 1999). including postreplicative DNA mismatch repair, genetic recombi- To facilitate the understanding of biological functions of nation, and cellular responses to DNA damaging agents (Buerm- MSH4 and MSH5 in mammals, we have now identified and char- eyer et al. 1999). During postreplicative mismatch repair, heterodi- acterized the mouse MutS homolog 4 (Msh4) by a homology- meric MutS homologous proteins initiate repair processes by rec- based cloning approach from a mouse testis Marathon-Ready ognizing and binding to the mispaired nucleotides (Kolodner cDNAs preparation (Clontech Laboratories, Palo Alto, Calif). The 1996). Germline mutations in at least five human mismatch repair
Mammalian Genome – Springer Journals
Published: Jan 1, 2001
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